Wound Healing Ointment Stability via Lipid Emulsifier System
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Solution Overview
Problem
Existing wound healing ointments face issues with stability, including changes in appearance, oiling out at elevated temperatures, and discoloration, which compromise their effectiveness and consumer acceptance.
Innovation Solution
A cosmetic or dermatological preparation comprising 0.8 to 3% by weight of glyceryl stearate and glyceryl stearate SE, along with ceresin, cera microcristallina, and paraffinum liquidum, while avoiding constituents of animal origin, ensuring stability and sensory appeal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If constituents of animal origin (lanolin, cholesterol) are used in the ointment formulation, then emulsifying and stabilizing properties are improved, but the formulation fails to meet consumer demands for animal-origin-free cosmetics
Solution Approach 1:
The patent removes constituents of animal origin (lanolin, cholesterol) from the formulation while extracting and retaining only the essential functional properties (emulsifying and stabilizing capabilities) through alternative synthetic or plant-based ingredients, thereby satisfying both performance requirements and consumer preferences for animal-origin-free cosmetics
Solution Approach 2:
The patent combines multiple synthetic and plant-based ingredients (glyceryl stearate, glyceryl stearate SE, ceresin, cera microcristallina, paraffinum liquidum) to collectively achieve the emulsifying and stabilizing functions previously provided by animal-derived components, creating a synergistic formulation that meets both performance and ethical criteria
2Reliability
If conventional ointment bases are used, then wound healing function is provided, but stability problems occur including appearance changes, oiling out at elevated temperatures, and discoloration
Solution Approach 1:
The patent modifies the chemical composition parameters of the ointment base by selecting specific ingredients with controlled proportions (0.8-3% glyceryl stearate, 0.8-3% glyceryl stearate SE, 8-15% ceresin, specific ranges of cera microcristallina and paraffinum liquidum) to achieve optimal stability across temperature ranges while maintaining wound healing efficacy, preventing oiling out and discoloration
Solution Approach 2:
The patent creates a composite ointment formulation integrating multiple lipid phases (ceresin, cera microcristallina, paraffinum liquidum) with specific emulsifiers (glyceryl stearate and its SE variant) to produce a structurally stable system that resists phase separation, maintains consistent appearance, and prevents oxidation-induced discoloration while supporting wound healing
3Ease of operation
If the ointment is stored at elevated temperatures and exposed to light, then distribution and usability are improved, but significant deterioration occurs including oiling out, discoloration, and odor degradation
Solution Approach 1:
The patent incorporates antioxidants and stabilizing ingredients (vitamin E, tocopherol) into the formulation before storage to preemptively protect against oxidation and degradation when exposed to elevated temperatures and light, preventing discoloration and odor deterioration while maintaining the ointment's spreadability and usability
Solution Approach 2:
The patent selects lipid components (ceresin, cera microcristallina, paraffinum liquidum) with high oxidation resistance and thermal stability, converting the potential harm of elevated temperature storage into an opportunity to demonstrate superior formulation stability, while the emulsifier system prevents oiling out even under stress conditions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation achieves enhanced stability, maintaining consistency and appearance over time, and provides regulatory freedom in formulation without compromising on animal origin-free ingredients, thus ensuring effective wound healing.
Implementation Method 1
a.) 0.8 to 3% by weight, particularly 1.2 to 1.8% by weight glyceryl stearate, b.) 0.8 to 3% by weight, particularly 1.2 to 1.8% by weight glyceryl stearate SE
Implementation Method 2
c.) one or more lipids selected from the group of ceresin, cera microcristallina and paraffinum liquidum
Data Source
AI summary
Described is a stable cosmetic or dermatological formulation, in particular a wound healing ointment, which comprises a.) 0.8 to 3 wt.-%, in particular 1.2 to 1.8 wt.-% glyceryl stearates, b.) 0.8 to 3 wt.-%, in particular 1.2 to 1.8 wt.-% glyceryl stearates SE, c.) one or more lipids selected from the group of ceresin, cera microcristallina and paraffinum liquidum, advantageously 8 to 12 wt.-%, in particular 9 to 11 wt.-% ceresin, d.) less than 1 wt.-% water, and e.) less than 0.1 wt.-% of each of cholesterol and lanolin alcohol.