Olanexidine Gluconate Basic Composition for Broad-Spectrum Viricidal Activity
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Solution Overview
Problem
Olanexidine gluconate-based disinfectants have limited efficacy against non-enveloped viruses and are not effective at higher pH levels, restricting their application in medical and food industries.
Innovation Solution
A basic antiseptic composition of olanexidine gluconate with a pH range of 8 to 11, optionally containing surfactants and antiseptic alcohols, enhances bactericidal and viricidal activities, including effectiveness against non-enveloped viruses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If olanexidine gluconate is used in a mildly acidic formulation (pH 5), then it shows good bactericidal activity against enveloped viruses, but it has no efficacy on non-enveloped viruses and limited bactericidal spectrum
Solution Approach 1:
The patent changes the pH parameter from mildly acidic (pH 5) to basic (pH 8-11), which fundamentally alters the chemical state of olanexidine gluconate. This parameter change enables the compound to exhibit efficacy against non-enveloped viruses and acid-fast bacteria while maintaining activity against enveloped viruses, thereby expanding the bactericidal spectrum without sacrificing existing efficacy
2Adaptability or versatility
If the pH of olanexidine gluconate solution is increased to basic level (pH 8-11), then the bactericidal spectrum is extended to include non-enveloped viruses, but the stability of the compound may be compromised
Solution Approach 1:
The patent introduces surfactants as intermediary substances that stabilize olanexidine gluconate in basic conditions. The surfactants form micellar structures that protect the compound from degradation at high pH while allowing it to maintain its expanded bactericidal spectrum, including activity against non-enveloped viruses and acid-fast bacteria
3Reliability
If chlorhexidine gluconate is used, then it shows viricidal action on enveloped viruses, but it has no efficacy on non-enveloped viruses and causes precipitation at pH 8 or more
Solution Approach 1:
The patent changes the chemical structure parameter by selecting olanexidine gluconate (a monobiganide compound) instead of chlorhexidine gluconate (a bisbiganide compound). This structural parameter change, combined with basic pH formulation, enables efficacy against non-enveloped viruses while avoiding the precipitation problem that occurs with chlorhexidine at high pH
4Adaptability or versatility
If polyhexamethylene biguanide is used, then it has broad bactericidal spectrum and is easily soluble in water, but it requires polymer structure which increases molecular complexity
Solution Approach 1:
The patent extracts the essential functional features of polyhexamethylene biguanide (broad spectrum activity and water solubility) and implements them through a simpler monobiganide structure (olanexidine gluconate). This extraction eliminates the need for complex polymer chains while retaining the desirable properties of broad bactericidal spectrum and ease of formulation
Data Source
AI summary
An antiseptic composition with a more extended applicable range by further enhancing the efficacy of olanexidine gluconate, which has been used as a highly safe dermal bactericidal disinfectant, and extending antibacterial spectrum. The antiseptic composition includes olanexidine gluconate and is basic and has a more extended bactericidal spectrum than conventional disinfectants.