Olefin Elastomer Patch Backing for Drug Sublimation Control
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Solution Overview
Problem
Existing patch backings for water-based pasty preparations face issues with pasty preparation retention, moisture retention, and drug efficacy due to sublimation, while also providing a sticky or restrained feeling during application, and lacking in elasticity and thin thickness.
Innovation Solution
A patch backing laminate structure consisting of three layers, with a film layer containing an olefin elastomer between two nonwoven fabric layers, featuring through-holes with specific opening ratios and areas to control moisture permeability and elasticity, ensuring excellent retention and feel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a microporous synthetic resin film and nonwoven fabric are used for patch backing, then the structure provides basic support and adhesive functionality, but the elasticity is insufficient resulting in poor application feeling
Solution Approach 1:
The patent changes the material parameter from conventional microporous synthetic resin to olefin elastomer, which inherently provides superior elasticity. This material substitution directly resolves the contradiction by maintaining structural integrity while dramatically improving elasticity and application comfort.
Solution Approach 2:
The patent creates a composite structure by laminating olefin elastomer film with nonwoven fabric layers. This composite approach combines the elasticity of olefin elastomer with the breathability and comfort of nonwoven fabric, achieving both improved elasticity and excellent application feeling simultaneously.
2Ease of operation
If the backing structure is made thinner to improve application feeling, then comfort increases, but retention of water-based pasty preparation and moisture retention deteriorate
Solution Approach 1:
The patent uses a multi-layer composite structure where each layer contributes specific functions: olefin elastomer provides elasticity and thin profile, while nonwoven fabric layers provide retention and moisture management. This composite approach allows thin overall thickness while maintaining excellent pasty preparation retention through the synergistic combination of materials.
Solution Approach 2:
The patent applies different material properties to different layers: the olefin elastomer layer provides local elasticity and flexibility, while the nonwoven fabric layers provide local retention and moisture absorption. This local differentiation of material qualities enables thin thickness for comfort while maintaining retention functionality.
3Quantity of substance
If opening ratio of through-holes is increased to improve moisture permeability, then breathability improves, but drug sublimation increases reducing efficacy persistence
Solution Approach 1:
The patent optimizes the through-hole parameters to specific ranges: opening ratio of 1-10% and area per hole of 0.02-0.18 mm². This precise parameter control allows sufficient moisture permeability for breathability while limiting drug sublimation to maintain efficacy persistence.
Solution Approach 2:
The patent creates local quality differentiation through the olefin elastomer material properties, where the through-holes provide localized moisture pathways while the surrounding matrix structure maintains drug retention. This local differentiation enables selective permeability that balances breathability with drug efficacy protection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively inhibits drug sublimation, enhances pasty preparation and moisture retention, provides excellent elasticity and a non-sticky feel, and ensures a comfortable application experience by maintaining moisture balance and flexibility.
Implementation Method 1
a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%
Implementation Method 2
the opening ratio of the through-hole is 1-10%, does not result in the closure of the openings in spite of using an elastomer, lowers the dampness by retaining the moisture permeability
Implementation Method 3
said film layer consists of a resin containing an olefin elastomer... because of the excellent stretch recovery, the backing is excellent in followability to a skin stretch and contraction
Implementation Method 4
because the both surfaces of the patch backing consist of nonwoven fabric layers, a peeling of the pasty preparation does not easily occur due to the anchor effect of the fiber constituting the nonwoven fabric layer
Data Source
AI summary
The present invention relates to a backing for a water-based patch consisting of the following constituents, wherein the backing is excellent in pasty preparation retention and moisture retention, improves the persistence of drug efficacy by inhibiting the sublimation of the drug, gives neither restrained feeling nor rough feeling due to a thin thickness and an excellent elasticity, controls the moisture permeability, gives almost no sticky feeling and thereby gives an excellent feeling in application. A patch backing for a water-based pasty preparation consisting of a laminate, wherein the laminate consists of three layers, a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%.