Vegetable Oleosome Encapsulation for Oxidation-Stable Bioactives

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Solution Overview

Problem

Existing colloidal systems lack improved oxidative stability and gastric stability for lipophilic dietary bioactive compounds, necessitating a better matrix for their delivery and protection.

Innovation Solution

A composition of loaded isolated vegetable oleosomes containing at least 80 wt.% lipophilic dietary bioactive substances, prepared by blending these substances with isolated vegetable oleosomes and subjecting the mixture to high-shear force, ensuring at least 80 wt.% of the bioactive substances are encapsulated within the oleosomes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing colloidal systems are used to deliver lipophilic dietary bioactive compounds, then delivery is achieved, but oxidative stability and gastric stability are insufficient

Engineering Contradiction:

Improveoxidative stabilityVSAvoidoxidation of bioactive compounds

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses oleosomes (natural lipid vesicles with flexible phospholipid bilayer membranes) to encapsulate lipophilic bioactive compounds. The flexible oleosome shells provide protective barrier function while maintaining stability against oxidation and gastric conditions, directly resolving the contradiction between delivery capability and oxidative stability.

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

The invention creates a composite system where lipophilic bioactive compounds are encapsulated within oleosomes formed by phospholipids and other lipids. This composite structure combines the protective properties of the oleosome membrane with the delivered bioactive compounds, achieving both delivery and oxidative stability simultaneously.

Inventive Principle:

Principle #40Composite materials

2Reliability

If existing colloidal systems are used to deliver lipophilic dietary bioactive compounds, then delivery is achieved, but stability in gastric phase is insufficient

Engineering Contradiction:

Improvegastric stabilityVSAvoidinstability in digestive tract

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The oleosome membranes provide a stable protective shell that maintains structural integrity during gastric passage. The phospholipid bilayer structure resists disruption by gastric conditions while still allowing controlled delivery, resolving the contradiction between achieving delivery and maintaining gastric stability.

Inventive Principle:

Principle #30Flexible shells and thin films

3Quantity of substance

If high concentration of lipophilic bioactive compounds is delivered, then nutritional value increases, but oxidative stability decreases

Engineering Contradiction:

Improveamount of bioactive compoundsVSAvoidoxidative stability

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent encapsulates lipophilic bioactive compounds within the interior of oleosomes, nesting the bioactive substances inside the protective lipid vesicles. This nesting structure allows high concentrations of bioactive compounds to be delivered while the oleosome shell provides oxidative protection, resolving the contradiction between quantity and stability.

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The oleosome membranes form protective shells around the concentrated bioactive compounds, providing a barrier against oxidation while containing high amounts of the active substances. This shell structure enables simultaneous achievement of high concentration delivery and oxidative stability.

Inventive Principle:

Principle #30Flexible shells and thin films

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The oleosome composition effectively protects and stabilizes lipophilic dietary bioactive substances, enhancing their stability in the gastric phase of the human digestive tract and preventing oxidation.

Implementation Method 1

subjecting the blend obtained from step a) to a high-shear force and obtaining an oleosome composition comprising loaded isolated vegetable oleosomes

Methodology Applied

Scientific EffectHigh-shear force: Shear Stress

Data Source

PatentUS20260090577A1Oleosome composition with bio-actives

Publication Date: 2026.04.02 CARGILL INC

AI summary

It relates to oleosome composition comprising loaded isolated vegetable oleosomes being isolated vegetable oleosomes loaded with one or more source of one or more lipophilic dietary bioactive substance and optionally additional lipids, which are present in the inside of the oleosomes and wherein at least 80 wt. % of the total weight of lipophilic dietary bioactive substance and at least 80 wt. % of the optionally additional lipids in the composition is present in the oleosomes. It relates to a product comprising the oleosome composition. It relates to a process for preparing such an olcosome composition, it relates further to the use of the oleosome composition as a carrier for one or more lipophilic dietary bioactive substance.