Oleosome Preservation Composition for Neutral pH Stability
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Solution Overview
Problem
Oleosome preparations are unstable in neutral pH due to microbial contamination and are destabilized by common preservatives, leading to oil leakage and reduced stability, making them unsuitable for cosmetic applications.
Innovation Solution
A method involving the treatment of oleosomes with a mixture of C1 to C5 branched diol compounds, C1 to C10 linear diol compounds, and glyceryl ether/ester compounds, along with a preservative, at a pH of 5.0 to 8.0, to enhance stability and inhibit microbial growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If acid or acid salt preservatives are used to protect oleosomes from microbial contamination, then antimicrobial effect is improved, but oleosome structure is weakened causing oil leakage and loss of physical stability
Solution Approach 1:
The patent changes the pH parameter from acidic (pH 4.0-5.0) to neutral (pH 6.0-8.0), which fundamentally alters the chemical environment. This parameter change allows preservatives to function effectively while maintaining oleosome structural integrity, as neutral pH prevents the acid-induced weakening of oleosome membranes that causes oil leakage
Solution Approach 2:
The patent introduces amine compounds as intermediary substances that mediate between preservatives and oleosomes. These amine compounds enable preservatives to exert antimicrobial effects without directly damaging oleosome structures, acting as a buffer or protective intermediary that preserves membrane integrity while allowing preservative function
2Stability of the object's composition
If neutral pH range is used to maintain oleosome stability and prevent oil leakage, then physical stability is improved, but microbial growth occurs reducing preparation stability
Solution Approach 1:
Amine compounds serve as intermediary substances that enable preservatives to function at neutral pH without damaging oleosomes. The amine compounds facilitate the antimicrobial action of preservatives while maintaining the neutral pH environment necessary for oleosome structural stability
Solution Approach 2:
The patent creates a composite preservation system combining preservatives with amine compounds. This composite approach allows the system to achieve both antimicrobial protection and physical stability at neutral pH, as the two components work synergistically to address both microbial contamination and oleosome integrity
3Stability of the object's composition
If pH is lowered below isoelectric point to stabilize oleosome preparation, then physical stability is improved, but skin irritation occurs making it unsuitable for cosmetic use
Solution Approach 1:
The patent changes the pH parameter from below isoelectric point (acidic) to above isoelectric point (neutral pH 6.0-8.0). This parameter change simultaneously achieves preparation stability and skin compatibility, as neutral pH avoids the skin irritation caused by acidic conditions while maintaining oleosome integrity through the combined preservative-amine system
Data Source
AI summary
The present invention relates to an oleosome preparation composition with excellent stability and antimicrobial activity, comprising a branched diol-based compound as an active ingredient and a method for preparing same. More specifically, by treating oleosomes with a mixture of a branched diol-based compound, a straight-chain diol-based compound, a glyceryl-based ether/ester compound, and other preservatives, the oleosomes have excellent formulation stability, exhibit excellent antimicrobial activity against bacteria, fungi, yeast, and the like, and have a preservative boosting effect.