Olfactory Receptor Screening for Specific Offensive Odor Suppression
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Solution Overview
Problem
There is a lack of known olfactory receptors responsive to 1-octen-3-one and 1,5-octadien-3-one, hindering the development of materials that effectively suppress these odors and associated off-flavors.
Innovation Solution
Identification of olfactory receptors OR2C1 and OR4Q3, which respond to 1-octen-3-one and 1,5-octadien-3-one, allowing for a screening method to evaluate and select materials that suppress these odors through the use of olfactory receptor antagonists.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional odor suppression methods are used, then general odor masking is achieved, but specific suppression of 1-octen-3-one and 1,5-octadien-3-one odors is insufficient
Solution Approach 1:
The patent introduces olfactory receptor polypeptides OR2C1 and OR4Q3 as intermediary tools to detect and screen substances that specifically suppress 1-octen-3-one and 1,5-octadien-3-one odors. These receptors act as mediators between the odor-causing substances and the screening system, enabling reliable identification of effective suppression materials.
2Measurement precision
If olfactory receptors OR2C1 and OR4Q3 are used for screening, then specific odor suppression capability is improved, but knowledge availability of responsive receptors was previously insufficient
Solution Approach 1:
The patent performs preliminary identification and characterization of olfactory receptors OR2C1 and OR4Q3 that respond to 1-octen-3-one and 1,5-octadien-3-one. By establishing this receptor knowledge base in advance, the screening system can immediately begin precise detection without requiring subsequent receptor discovery efforts.
3Ease of operation
If human sensory testing is used, then subjective odor perception is measured, but olfactory fatigue and individual variations affect reliability
Solution Approach 1:
The patent replaces the human sensory testing system with a biochemical detection system using olfactory receptor polypeptides OR2C1 and OR4Q3. This substitution eliminates human olfactory fatigue and individual variations while maintaining operational simplicity through standardized biochemical assays.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables the development of materials that effectively suppress age-related body odors, underarm odors, and off-flavors by identifying candidate substances that reduce the response of OR2C1 and OR4Q3, overcoming issues of olfactory fatigue and individual variations.
Implementation Method 1
adding a test substance and one or more offensive odor-causing substances selected from the group consisting of 1-octen-3-one and 1,5-octadien-3-one to at least one olfactory receptor polypeptide selected from the group consisting of (a) OR2C1 and OR4Q3
Implementation Method 2
measuring the response of the olfactory receptor polypeptide to the one or more offensive odor-causing substances; and identifying a test substance that suppresses the response of the olfactory receptor polypeptide
Data Source
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AI summary
The present invention relates to a screening method for materials suppressing one or more offensive odors selected from the group consisting of a 1-octen-3-one odor, a 1,5-octadien-3-one odor, a 1-octen-3-ol odor and a 1,5-octadien-3-ol odor, an offensive odor-suppressing composition for reducing the offensiveness of age-related body odors and/or underarm odors, as well as a flavor composition for reducing off-flavors derived from food and beverage products. By using the screening method of the present invention, candidate substances for materials suppressing a 1-octen-3-one odor, a 1,5-octadien-3-one odor, a 1-octen-3-ol odor and a 1,5-octadien-3-ol odor can be selected respectively from among many test substances. An offensive odor-suppressing composition comprising an active ingredient selected by using the screening method of the present invention can be expected to contribute to reduction in the offensiveness of age-related body odors and/or underarm odors and to reduction in off-flavors derived from food and beverage products.