Oligonucleotide Sol-Gel Composition for Oral Cavity Persistence
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Solution Overview
Problem
Existing technologies face challenges in effectively administering and releasing oligonucleotides, particularly in the oral cavity, where high fluid levels hinder persistence and uptake, and there is a need for improved delivery systems for treating chronic inflammatory diseases like periodontitis.
Innovation Solution
A composition comprising oligonucleotides, Poloxamer 188 and Poloxamer 407 copolymers, and a medium, which undergoes a sol-gel transition, ensuring persistence and efficient release of oligonucleotides in inflammatory regions like the oral cavity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If oligonucleotides are administered in the oral cavity, then therapeutic effect is achieved, but high fluid levels cause rapid clearing and reduced persistence
Solution Approach 1:
The patent changes the physical state parameter of the composition by utilizing sol-gel transition. The composition transitions from a liquid state (easy to apply) to a gel state (provides persistence), allowing the oligonucleotide to remain at the application site despite high fluid levels in the oral cavity
Solution Approach 2:
The patent employs a composite system combining oligonucleotide with copolymers that exhibit sol-gel transition properties. This composite material provides both the therapeutic agent and the delivery vehicle with controlled release properties, overcoming the rapid clearing effect of oral fluids
2Duration of action of moving object
If controlled release is achieved through sol-gel transition, then drug persistence is improved, but composition complexity increases
Solution Approach 1:
The patent utilizes the phase transition phenomenon of sol-gel transition in copolymer systems. This natural physical transition provides controlled release functionality without requiring complex mechanical or electronic control systems, achieving persistence through a relatively simple compositional approach
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides controlled and efficient release of oligonucleotides, enhancing drug persistence and uptake, while minimizing whole-body exposure and reducing side effects, suitable for treating conditions such as periodontitis and gingivitis.
Implementation Method 1
A composition comprising oligonucleotides, Poloxamer 188 and Poloxamer 407 copolymers, and a medium, which undergoes a sol-gel transition
Data Source
AI summary
The present invention relates to a composition comprising an oligonucleotide, at least two copolymers with at least two of the copolymers being Poloxamer 188 and Poloxamer 407, and a medium. The present invention further relates to a method for preparing said composition.