Olive Polyphenol Antiviral Composition for SARS-CoV-2 Inactivation

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Solution Overview

Problem

Current measures for preventing and treating viral infections, such as those caused by SARS-CoV-2, lack effective natural-derived supplementary agents and methods for surface disinfection, necessitating the development of auxiliary approaches for prevention and symptom management.

Innovation Solution

The use of an olive component composition comprising polyphenolic compounds like hydroxytyrosol, oleuropein, and others, administered orally or applied topically, to prevent viral infections and inactivate viruses on surfaces, formulated into antiviral compositions for inhalation and surface treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If chemical disinfectants are used to inactivate environmental viruses, then viral inactivation is achieved, but the lack of effective natural-derived supplementary agents limits preventive and therapeutic options

Engineering Contradiction:

Improvepreventive and therapeutic optionsVSAvoidreliance on chemical disinfectants

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces olive-derived polyphenolic compounds as intermediary natural agents that mediate between viral inactivation and human health protection. These compounds serve as supplementary preventive and therapeutic agents, reducing reliance on purely chemical disinfectants while maintaining viral inactivation efficacy through natural biochemical mechanisms.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the chemical parameters by utilizing polyphenolic compounds with specific molecular structures (hydroxytyrosol, oleuropein, tyrosol esters of elenolic acid) that possess antiviral properties. This parameter change enables natural-derived agents to achieve viral inactivation, expanding the range of safe and effective preventive and therapeutic options.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If existing measures like vaccination and medication are used, then viral infection prevention is achieved, but the need for auxiliary natural approaches increases demand for supplementary agents

Engineering Contradiction:

Improveviral infection preventionVSAvoidsupplementary agents

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent develops olive-derived polyphenolic compounds that serve multiple functions: they act as preventive agents, therapeutic supplements, and natural disinfectants. This multi-functionality enables a single natural substance to address various aspects of viral infection management, increasing adaptability and versatility in preventive and therapeutic strategies.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent utilizes composite formulations containing multiple polyphenolic compounds (hydroxytyrosol, oleuropein, tyrosol esters of elenolic acid, and other olive-derived phenolics) that work synergistically to enhance antiviral efficacy. This composite approach provides robust viral infection prevention while offering versatile supplementary therapeutic options.

Inventive Principle:

Principle #40Composite materials

3Adaptability or versatility

If natural-derived compositions are developed as supplemental agents, then preventive and therapeutic options are expanded, but the complexity of formulating and validating antiviral compositions increases

Engineering Contradiction:

Improvepreventive and therapeutic optionsVSAvoidformulation and validation process

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent segments the complex olive-derived composition into specific identified polyphenolic compounds (hydroxytyrosol, oleuropein, tyrosol esters of elenolic acid) and their respective functions. This segmentation simplifies the formulation and validation process by allowing targeted development of individual active components while maintaining the overall synergistic effect of the natural-derived composition.

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The olive component composition demonstrates significant virucidal activity against SARS-CoV-2, including variants, reducing viral titers and inhibiting viral proliferation, offering a natural and effective supplementary approach for infection prevention and symptom management.

Implementation Method 1

The olive component composition demonstrates significant virucidal activity against SARS-CoV-2, including variants, reducing viral titers and inhibiting viral proliferation

Methodology Applied

Scientific EffectVirucidal activity:

Implementation Method 2

reducing viral titers and inhibiting viral proliferation, offering a natural and effective supplementary approach for infection prevention and symptom management

Methodology Applied

Scientific EffectViral proliferation inhibition:

Data Source

PatentUS20240165187A1Antiviral olive extract compositions and methods

Publication Date: 2024.05.23 CREA ROBERTO

AI summary

An olive component composition with anti-viral activity is disclosed. The olive component composition can be used to prevent, treat, or ameliorate symptoms of, viral infection.