Olive Polyphenol Concentration via Ceramic Membrane Filtration
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Solution Overview
Problem
Current methods for addressing pathological angiogenesis and inflammation, particularly in tumors, are inefficient due to the irregular structure of tumor blood vessels, which hinders drug delivery, and olive oil by-products like vegetation water and pomace, rich in polyphenols, are underutilized and generate environmental pollution.
Innovation Solution
A process involving microfiltration using ceramic membranes and subsequent reverse osmosis with polyamide membranes to concentrate polyphenolic compounds like hydroxytyrosol and 3,4-DHPA-EDA from olive vegetation water and pomace, creating a phytocomplex that inhibits pathological angiogenesis and inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drug delivery methods are used to treat tumors, then drugs can be administered systemically, but the irregular structure of tumor blood vessels causes drugs to disperse in interstitial liquid rather than reaching the tumor, reducing treatment effectiveness
Solution Approach 1:
The patent applies angioprevention by administering compounds that block angiogenic factors before tumors can develop abnormal blood vessels. This preliminary action prevents the formation of irregular vessels that would otherwise hinder drug delivery, ensuring that when chemotherapy is administered, the vascular structure is already optimized for effective drug transport to the tumor site
2Loss of energy
If olive oil by-products (vegetation water and pomace) are disposed of conventionally, then waste management is simplified, but these rich polyphenolic compounds generate environmental pollution and represent lost pharmaceutical potential
Solution Approach 1:
The patent converts the harmful waste by-products of olive oil production into beneficial pharmaceutical compounds. By extracting polyphenols from vegetation water and pomace that would otherwise pollute the environment, the process transforms environmental hazards into anti-angiogenic and anti-inflammatory medications, simultaneously solving pollution problems and creating therapeutic agents
Solution Approach 2:
The patent implements recovery of valuable polyphenolic compounds from olive oil by-products that are normally discarded. Through extraction processes using solvents like ethanol or supercritical CO2, the method recovers hydroxytyrosol, oleuropein, and other polyphenols from waste streams, converting disposal operations into resource recovery processes
3Quantity of substance
If polyphenolic compounds are extracted from olive by-products using conventional methods, then extraction can be performed simply, but the efficiency and concentration of anti-angiogenic compounds are insufficient for therapeutic use
Solution Approach 1:
The patent employs supercritical fluid extraction where carbon dioxide is transformed from gaseous to supercritical state by changing pressure and temperature parameters. This parameter change enables the CO2 to achieve liquid-like density and gas-like diffusivity, dramatically increasing extraction efficiency and compound concentration compared to conventional solvent methods, while allowing easy recovery of pure polyphenols by depressurization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The concentrated phytocomplex effectively prevents the formation of tumor blood vessels, improving drug delivery and offering a sustainable solution to environmental pollution by valorizing olive oil by-products, demonstrating enhanced anti-angiogenic and anti-inflammatory effects compared to using hydroxytyrosol alone.
Implementation Method 1
microfiltration using ceramic membranes
Implementation Method 2
reverse osmosis with polyamide membranes
Data Source
Figure 1A~1D
Figure 2A~2D
Figure 3A~3D
AI summary
The present invention relates to a phytocomplex or natural concentrate rich in polyphenolic compounds, such as hydroxytyrosol and 3,4-DHPA- EDA, derived from the vegetation waters of oil-bearing olives or from olive pomace resulting from the olive milling process for use in the treatment and prevention of angiogenesis and inflammation. In particular, the angiogenesis and inflammation to which reference is made is pathologic angiogenesis and inflammation, for example that which sustains the development and spread of a tumor or angiogenesis and inflammation tied to non-tumor pathologies. The present invention further relates to a beverage comprising the polyphenol concentrate and the use thereof in the treatment and prevention of angiogenesis and inflammation.