Omega-3 Amino Acid Salt Composition for Enhanced Bioavailability
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Solution Overview
Problem
Current dietary supplements and food fortifications with omega-3 fatty acids, such as EPA and DHA, face challenges in bioavailability due to low solubilization and enzymatic hydrolysis in the fasted state, leading to incomplete absorption, especially when administered independently of meals.
Innovation Solution
A composition combining amino acid salts of omega-3 fatty acids (EPA or DHA) with specific anthocyanins like cyanidin-3-glucoside, delphinidin-3-glucoside, malvidin-3-galactoside, and peonidin-3-galactoside, which enhances bioavailability and vasorelaxant effects by improving nitric oxide production and reducing oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If omega-3 fatty acid supplements are administered independently from meals in the form of capsules or pills, then convenience of consumption is improved, but bioavailability and solubilization are reduced due to lack of digestive fluid secretion
Solution Approach 1:
The patent changes the physical-chemical parameters of omega-3 fatty acids by converting them into salt forms (sodium, potassium, calcium, magnesium, or ammonium salts). This transformation improves solubility and bioavailability without requiring meal-associated digestive fluids, thus resolving the contradiction between convenient standalone administration and reliable absorption
Solution Approach 2:
The invention creates composite nutritional formulations that combine omega-3 fatty acid salts with other nutrients or functional ingredients. This composite approach enhances the overall bioavailability and effectiveness of the supplement when taken independently from meals, addressing both convenience and reliability requirements
2Manufacturing precision
If advanced formulation technologies with release polymers are used to release omega-3 fatty acids in the lower digestive system, then targeted delivery is improved, but natural solubilization mechanisms become less effective reducing bioavailability
Solution Approach 1:
By transforming omega-3 fatty acids into salt forms with inherently improved solubility characteristics, the invention compensates for the reduced effectiveness of natural solubilization mechanisms in the lower digestive system. This allows targeted delivery via release polymers to maintain high bioavailability despite the absence of upper GI tract digestive fluids
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly improves endothelial function, reduces oxidative stress, and enhances the bioavailability of omega-3 fatty acids, providing a potent vasorelaxant effect and antioxidant action, particularly in the context of cardiovascular health.
Implementation Method 1
enzymatic hydrolysis of fats and oils, low solubilization and bioavailability
Implementation Method 2
direct scavenging of reactive oxygen species
Implementation Method 3
increasing pro-oxidant factors and often also by the development of endothelium-dependent contracting responses
Data Source
AI summary
A composition for use as antioxidant, where the composition has at least one polyunsaturated fatty acid component and at least one anthocyanin component. The polyunsaturated fatty acid component is an amino acid salt of the omega-3 fatty acids eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). The anthocyanin component is cyanidin-3-glucoside, delphinidin-3-glucoside, malvidin-3-galactoside, peonidin-3-galactoside, or malvidin-3-glucoside. A method for treating a disease with the composition. A method of providing an antioxidant to a subject with the composition.