Omega-3 Phospholipid Compositions for Better Oral Tolerability
Solution Overview
Problem
Oral administration of omega-3 compositions often results in unwanted side effects such as burping and reflux, and there are limitations in the biological availability of some forms of omega-3 fatty acids.
Innovation Solution
Compositions comprising omega-3 phospholipids in combination with other omega-3 derivatives, including phospholipid compounds with a high percentage of choline moieties and omega-3 fatty acid moieties, and mixtures of omega-3 fatty acid derivatives such as glycerides, esters, and free fatty acids, are formulated to enhance bioavailability and reduce adverse reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral administration of omega-3 compositions is used, then cardiovascular health benefits are achieved, but unwanted side effects such as burping and reflux occur
Solution Approach 1:
The patent changes the chemical form of omega-3 fatty acids from triglycerides to phospholipids, specifically using phosphatidylcholine and phosphatidylethanolamine forms. This parameter change in molecular structure improves bioavailability and reduces gastrointestinal side effects like burping and reflux while maintaining cardiovascular benefits.
Solution Approach 2:
The invention uses composite phospholipid formulations combining multiple phospholipid types (phosphatidylcholine, phosphatidylethanolamine, and other phospholipids) with specific ratios to optimize both therapeutic efficacy and tolerability, reducing adverse effects while maintaining health benefits.
2Reliability
If conventional omega-3 formulations are used, then triglyceride reduction is achieved, but biological availability is limited
Solution Approach 1:
The patent transforms omega-3 fatty acids from triglyceride form to phospholipid form, specifically incorporating them into phosphatidylcholine and phosphatidylethanolamine molecules. This parameter change in chemical structure significantly enhances biological availability and absorption efficiency while maintaining triglyceride-lowering effects.
Solution Approach 2:
The invention uses phospholipids as molecular carriers that replicate and enhance the bioactive effects of omega-3 fatty acids, with the phospholipid structure itself serving as an absorption vehicle that improves cellular uptake and utilization of the omega-3 components.
Data Source
AI summary
The present invention relates to compositions comprising omega-3 fatty acid derivatives, and in particular to compositions comprising omega-3 phospholipids in combination with other omega-3 derivatives.