Ophthalmic Composition Merging Anesthetic and Antiseptic

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Solution Overview

Problem

Current ophthalmic procedures for intraocular injections are time-consuming and risky due to the sequential administration of anesthetics and antiseptics, which can cause discomfort and increase the risk of infection, especially with the use of high concentrations of povidone-iodine and separate saline irrigation.

Innovation Solution

A composition combining povidone-iodine at a concentration between 0.01% and 5.0% and proparacaine hydrochloride at a concentration between 0.2% and 0.6% is developed, which can be administered simultaneously to provide both anesthesia and antisepsis, reducing the need for multiple applications and saline irrigation, thereby minimizing discomfort and infection risk.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If sequential administration of anesthetic and antiseptic is used, then adequate anesthesia and antisepsis are achieved, but procedure time increases and patient discomfort increases

Engineering Contradiction:

Improveanesthesia and antisepsis effectivenessVSAvoidprocedure time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent combines the anesthetic agent (proparacaine hydrochloride) and antiseptic agent (povidone-iodine) into a single ophthalmic composition that can be administered simultaneously. This merging of two separate medications into one formulation allows both anesthesia and antisepsis to be achieved in a single application, eliminating the need for sequential administration and reducing procedure time while maintaining both therapeutic effects.

Inventive Principle:

Principle #5Merging (Combining)

2Reliability

If sequential administration of anesthetic and antiseptic is used, then adequate anesthesia and antisepsis are achieved, but patient discomfort increases

Engineering Contradiction:

Improveanesthesia and antisepsis effectivenessVSAvoidpatient discomfort

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

By combining the anesthetic and antiseptic into a single composition, the patent eliminates the need for multiple separate applications that cause discomfort. The single simultaneous administration reduces cumulative irritation and discomfort while ensuring both anesthesia and antisepsis are achieved effectively.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent optimizes the concentrations of proparacaine hydrochloride (0.2-0.6%) and povidone-iodine (0.01-5.0%) within the composition to achieve effective anesthesia and antisepsis while minimizing irritation and discomfort. This parameter optimization allows the formulation to be both effective and comfortable for patients.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If high concentration of povidone-iodine is used, then antisepsis effectiveness is improved, but patient discomfort and infection risk increase

Engineering Contradiction:

Improveantisepsis effectivenessVSAvoidpatient discomfort and infection risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent specifies a concentration range for povidone-iodine (0.01-5.0%, preferably 0.5-2.0%) that balances antisepsis effectiveness with reduced irritation and infection risk. This optimized concentration range maintains adequate antimicrobial activity while minimizing the harmful effects associated with high concentrations.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite ophthalmic composition combining proparacaine hydrochloride and povidone-iodine in specific proportions. This composite formulation allows the antiseptic to be delivered at an optimized concentration that is both effective and tolerable, while the combination itself enhances the overall therapeutic benefit while reducing side effects.

Inventive Principle:

Principle #40Composite materials

4Reliability

If separate administration of anesthetic and PVI is used, then adequate anesthesia and antisepsis are achieved, but procedure complexity increases

Engineering Contradiction:

Improveanesthesia and antisepsis effectivenessVSAvoidprocedure complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges the administration of anesthetic and antiseptic into a single simultaneous application of one composition. This eliminates the need for multiple separate steps, waiting periods, and applications, thereby simplifying the procedure while maintaining both anesthesia and antisepsis effectiveness.

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces procedure time, minimizes discomfort, and lowers infection risk by providing simultaneous anesthesia and antisepsis, making ophthalmic procedures safer and more efficient.

Implementation Method 1

Povidone-iodine in a concentration between about 0.01% and about 5.0% by weight

Methodology Applied

Scientific EffectIodine release:

Implementation Method 2

proparacaine hydrochloride in a concentration between about 0.2% and about 0.6% by weight

Methodology Applied

Scientific EffectLocal anesthesia:

Data Source

PatentUS20230172972A1Ophthalmic composition and method of use

Publication Date: 2023.06.08 AWH CARL C

AI summary

Ophthalmic compositions for administration to an eye including a mixture of an antiseptic and an anesthetic in therapeutically effective amounts are disclosed. The compositions are both anesthetic and antiseptic, and can be used in various ophthalmic procedures.