Ophthalmic Composition Retention via Surface Tension Modification
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Solution Overview
Problem
Existing eye medication compositions are often ineffective due to rapid washaway by natural eye processes, requiring frequent administration and high concentrations, which can lead to unwanted side effects.
Innovation Solution
Compositions incorporating a retention component that enhances retention and penetration through the cornea by reducing wettability, increasing meniscus height, muco-adhesion, viscosity, and physical apposition, allowing for prolonged delivery of therapeutic components without frequent readministration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional eye medication compositions are used, then the medication can be administered to the eye, but the composition is rapidly washed away by natural eye processes requiring frequent administration
Solution Approach 1:
The patent modifies the surface tension parameter of the eye composition by adding surfactants, changing it from low (conventional) to high (invention). This parameter change increases wettability and extends retention time on the cornea, reducing the frequency of administration needed to maintain therapeutic effect
Solution Approach 2:
The patent creates a composite composition combining multiple components: therapeutic agent, surfactant (surface active agent), and ophthalmically acceptable carrier. This composite structure provides both the therapeutic function and the extended retention function through the surfactant's surface tension modification properties
2Reliability
If high concentration of medication is used to compensate for rapid washaway, then therapeutic effectiveness is maintained, but unwanted side effects increase
Solution Approach 1:
By changing the surface tension parameter through surfactant addition, the composition achieves extended retention at lower medication concentrations. This allows maintaining therapeutic effectiveness (reliability) while reducing the harmful side effects associated with high concentration formulations
3Reliability
If frequent administration is performed to maintain therapeutic effect, then medication effectiveness is sustained, but patient convenience and compliance decrease
Solution Approach 1:
The surfactant-induced surface tension change extends composition retention time on the cornea, allowing sustained therapeutic effect with less frequent administration. This improves ease of operation and patient compliance while maintaining reliability of therapeutic effect
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions provide extended retention and increased penetration of therapeutic components, reducing the need for frequent administration and minimizing side effects while maintaining efficacy.
Implementation Method 1
The present compositions may have a surface tension greater than or equal to human tear fluid
Implementation Method 2
The retention component is advantageously effective to provide the compositions of the invention with, for example, an increased retention to or on the cornea of an eye when applied to the eye relative to substantially identical compositions without the retention component
Data Source
AI summary
The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.