Optical Analyte Imaging for Non-Invasive Glucose Signal Separation
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Solution Overview
Problem
Existing analyte testing technologies face challenges such as invasiveness, high cost, complexity, and inability to achieve real-time, portable non-invasive testing, particularly in methods like electrochemical and Raman spectroscopy, which suffer from inaccuracies due to mixed spectral signals and environmental factors.
Innovation Solution
A method and system utilizing infrared and ultraviolet light to image and obtain spectral data from specific areas of the skin, employing fluorescence spectroscopy and a trained model to analyze the data, enabling non-invasive, cost-effective, and real-time testing of analytes like glucose without piercing the skin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Raman spectroscopy is used for non-invasive analyte testing, then measurement precision is improved, but device complexity and cost increase significantly
Solution Approach 1:
The patent extracts and eliminates the harmful mixed spectral signals from skin tissues and other components by using a selective imaging method that captures only the analyte-specific fluorescence signals from blood vessels, thereby simplifying the system while maintaining measurement precision
Solution Approach 2:
The patent replaces the complex Raman spectroscopy system with a fluorescence-based optical imaging system that uses standard imaging components and light sources, significantly reducing device complexity and cost while achieving comparable or superior measurement precision
2Ease of operation
If absorption spectroscopy is used for non-invasive blood glucose testing, then non-invasive measurement is achieved, but spectral signal separation becomes difficult due to mixed signals from different components
Solution Approach 1:
The patent applies local quality by targeting specific regions (blood vessels) where the analyte is concentrated, using spatially selective imaging to capture fluorescence signals only from these regions, thereby eliminating mixed signals from surrounding skin tissues and other components
Solution Approach 2:
The patent utilizes the characteristic fluorescence emission wavelengths (colors) of the analyte to distinguish and separate its spectral signal from background signals, using wavelength-specific detection to isolate the analyte signal through spectral filtering
3Loss of information
If multiple sensors and modules are used to collect various biological signals, then information completeness is improved, but device complexity and cost increase, and portability is reduced
Solution Approach 1:
The patent makes a single optical imaging system perform multiple functions by capturing both spatial distribution information and spectral information simultaneously, eliminating the need for separate sensors and modules while maintaining information completeness
Solution Approach 2:
The patent merges the functions of multiple separate biological signal collection devices into a single integrated optical imaging system that can acquire all necessary information through one imaging process, thereby reducing device complexity and enabling portability
4Productivity
If electrochemical sensors are implanted subcutaneously for real-time glucose monitoring, then real-time data collection is improved, but invasiveness increases
Solution Approach 1:
The patent replaces the invasive electrochemical sensor implantation with a non-invasive optical imaging method that uses light to detect analyte concentrations through the skin, eliminating the need for physical penetration or implantation while maintaining real-time monitoring capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate, non-invasive, and cost-effective real-time testing of analytes by distinguishing spectral signals from different skin areas, excluding non-analyte influences, and using fluorescence spectroscopy for miniaturized and portable systems.
Implementation Method 1
the light in the second wavelength range can cause the analyte to excite a fluorescence radiation signal
Data Source
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AI summary
The present invention provides a method and a system for testing an analyte, a medium, and a device which relate to the field of optical analysis. The method comprises: imaging: irradiating a first area by light within a preset wavelength range, and imaging the first area, to obtain an image of an imaging area; spectrum obtaining: obtaining, from the image, spectral data that indicate uneven distribution in the imaging area of a reflection signal or an excitation signal generated by the analyte when irradiated by light; and analyzing step: obtaining information about the analyte in the imaging area based on the obtained spectral data, wherein the information about the analyte comprises information about the analyte correlated to the spectral data.