Optical Analyte Testing Using IR Vessel Imaging and UV Fluorescence
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Solution Overview
Problem
Existing analyte testing technologies face challenges such as invasiveness, high cost, complexity, and difficulty in achieving real-time, portable, and accurate non-invasive measurements, particularly in glucose testing, due to issues with electrochemical methods, Raman spectroscopy, and multi-wavelength systems.
Innovation Solution
A method and system utilizing single-wavelength infrared and ultraviolet light imaging to distinguish between areas with and without blood vessels, combined with fluorescence spectroscopy, to obtain accurate spectral data for analyte concentration analysis, employing a trained analyte testing model to process infrared light intensity and fluorescence spectral data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If electrochemical method is used for analyte testing, then real-time testing and portability are achieved, but invasiveness increases and manufacturing complexity increases
Solution Approach 1:
The patent replaces the electrochemical sensing mechanism with optical detection methods. Specifically, it uses fluorescence spectroscopy to detect analyte concentration through optical signals rather than electrochemical reactions, thereby eliminating the need for invasive sensors while maintaining real-time testing capability
Solution Approach 2:
The patent introduces fluorescence as an intermediary signal to bridge the gap between the analyte and the detection system. By using fluorescence emission from the analyte or its interaction with light, the system can non-invasively measure analyte concentration without direct contact with the body, thus reducing invasiveness while maintaining real-time measurement capability
2Measurement precision
If Raman spectroscopy is used for non-invasive testing, then accuracy is improved, but device complexity and cost increase
Solution Approach 1:
The patent employs fluorescence spectroscopy which uses simpler, more affordable light sources and detectors compared to Raman spectroscopy. The fluorescence detection system can be implemented with conventional optical components rather than requiring complex Raman scattering detection systems, thereby reducing device complexity and cost while maintaining accuracy
Solution Approach 2:
The patent changes the detection parameter from Raman scattering intensity to fluorescence emission intensity. By utilizing fluorescence, which has stronger signal intensity and better signal-to-noise ratio, the system achieves comparable or superior accuracy with simpler instrumentation, thus reducing device complexity while maintaining measurement precision
3Measurement precision
If multi-wavelength imaging is used to distinguish blood vessels, then measurement precision is improved, but device complexity and cost increase
Solution Approach 1:
The patent applies fluorescence spectroscopy at specific locations (blood vessel regions) to detect analyte concentration. By focusing the fluorescence detection on areas with blood vessels where the analyte is present, the system achieves high measurement precision without requiring complex multi-wavelength imaging across the entire body surface, thus reducing device complexity
Solution Approach 2:
The patent uses fluorescence as an intermediary signal to indirectly detect blood vessel locations and analyte concentration. Instead of directly imaging blood vessels using complex multi-wavelength techniques, the system uses fluorescence emission from the analyte in blood vessels as a mediator to identify both the vessel locations and analyte concentration simultaneously, simplifying the imaging system while maintaining precision
4Loss of information
If spectral signals from multiple components are collected, then comprehensive information is obtained, but measurement precision decreases due to signal mixing
Solution Approach 1:
The patent segments the spectral signal analysis by using fluorescence spectroscopy to isolate the analyte-specific signal from other background signals. By focusing on the fluorescence emission spectrum characteristic of the analyte, the system can separate and quantify the analyte concentration independently from other body components, thereby maintaining measurement precision while still obtaining comprehensive information about the analyte distribution
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables non-invasive, cost-effective, and real-time analyte testing with high accuracy by distinguishing vessel locations, excluding non-analyte influences, and correlating spectral data directly with analyte concentration, thus improving testing comfort and precision.
Implementation Method 1
irradiating a first area by single-wavelength infrared light within a first wavelength range, and imaging the first area, to obtain a first image of an imaging area
Implementation Method 2
irradiating the first area by ultraviolet light within a second wavelength range, and imaging the first area, to obtain a second image of the imaging area; and based on the grayscale distribution data, obtaining, from the second image, fluorescence spectral data at the desired position
Data Source
AI summary
The present invention provides a method and a system for testing an analyte, a medium, and a device. The method includes: imaging step: irradiating a first area by single-wavelength infrared light within a first wavelength range, and imaging the first area, to obtain a first image of an imaging area; and irradiating the first area by ultraviolet light within a second wavelength range, and imaging the first area, to obtain a second image of the imaging area; spectral obtaining step: obtaining, from the first image, grayscale distribution data that indicate the analyte; based on the grayscale distribution data, respectively obtaining, from the first image and the second image, infrared light intensity values and fluorescence spectral data at desired positions that demonstrate the analyte; and analyzing step: obtaining information about the analyte in the imaging area based on the infrared light intensity values and the fluorescence spectral data.