Optical Biochemical Profiling for Non-Invasive Intoxication Detection
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Solution Overview
Problem
Existing methods for determining physiological states, such as intoxication, rely on invasive blood sampling and are unreliable due to the redistribution of THC and THC-COOH in fatty tissues, making them unsuitable markers for cannabis intoxication.
Innovation Solution
A non-invasive method using electromagnetic radiation (EMR) across a range of wavelengths to measure multiple analytes in blood and interstitial fluid, followed by quantitative analysis and comparison to reference values to determine a biochemical profile indicative of the physiological state.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive blood sampling is used to measure THC and THC-COOH concentrations, then measurement accuracy is improved, but the reliability of the physiological state determination deteriorates due to tissue redistribution of THC
Solution Approach 1:
The patent replaces the mechanical invasive blood sampling system with a non-invasive optical measurement system. A probe containing light sources and detectors is placed on the skin to measure optical properties of tissue, which indirectly reflects biochemical concentrations including THC and its metabolites, eliminating the need for blood draws while improving measurement reliability through direct tissue analysis
Solution Approach 2:
The patent introduces optical properties (absorbance, reflectance, or transmittance) as an intermediary parameter to indirectly measure THC and THC-COOH concentrations. Instead of directly measuring blood concentrations, the system measures how light interacts with tissue, which serves as a mediator that reflects the presence and concentration of target analytes without requiring invasive sampling
2Reliability
If multiple analytes are measured using non-invasive optical methods, then the reliability of physiological state determination is improved, but the device complexity increases
Solution Approach 1:
The patent designs a universal optical measurement system that can detect multiple analytes (THC, THC-COOH, and other biochemical markers) simultaneously using the same basic principle of optical interaction with tissue. The system uses multiple light sources at different wavelengths and a spectrometer to capture broad spectral data, which can then be analyzed to identify and quantify various analytes, making the device multi-functional for different measurement applications
Solution Approach 2:
The patent segments the optical measurement process into distinct functional components: light sources emitting at multiple wavelengths, a spectrometer for spectral analysis, and processing units that analyze specific wavelength regions. This segmentation allows the complex measurement of multiple analytes to be broken down into manageable optical and computational steps, improving reliability through comprehensive multi-analyte detection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides accurate, non-invasive determination of physiological states like intoxication by measuring a plurality of analytes, enhancing reliability and enabling timely corrective actions.
Implementation Method 1
directing a source of electromagnetic radiation (EMR) over a range of wavelengths through the receptor and onto body part so that the EMR reaches the blood and interstitial fluid within the body part
Implementation Method 2
measuring the EMR absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part with a detector to obtain a spectrum over the range of wavelengths
Implementation Method 3
measuring the EMR absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part with a detector to obtain a spectrum over the range of wavelengths
Data Source
AI summary
A method for non-invasively determining a physiological state of interest in a subject is described. The method involves, placing a body part in contact with a receptor, and directing a source of electromagnetic radiation (EMR) over a range of wavelengths onto body part so that the EMR reaches the blood and interstitial fluid within the body part. The EMR that is absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part is measured, and a spectrum over the range of wavelengths obtained. The spectrum is analyzed to determine an amount of two or more than two analytes within the blood and interstitial fluid of the body part and a biochemical profile is derived. The biochemical profile is used to determine the physiological state of interest in the subject. The physiological state of interest in the subject may be selected from the group of intoxication arising from cannabis, alcohol, a combination of cannabis and alcohol, opiates, fentanyl, amphetamines, phencyclidine, sedatives, anxyolytics, cocaine, caffeine, and nicotine consumption.


