Optical Fiber Catheter for Myocardial Tissue Conditioning
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Solution Overview
Problem
Current therapies lack effective solutions for conditioning myocardial tissues to prevent or reduce reperfusion injury during endovascular treatments for coronary heart diseases like STEMI.
Innovation Solution
A method using an optical fiber catheter to deliver light with wavelengths between 510 nm and 830 nm to myocardial tissues during endovascular therapy, reducing reperfusion injury.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If endovascular therapy is administered to restore coronary blood flow, then myocardial reperfusion is achieved, but reperfusion injury occurs to the underlying myocardial tissues
Solution Approach 1:
The patent applies preliminary action by delivering light conditioning therapy to myocardial tissues before endovascular reperfusion therapy. The optical fiber catheter delivers light in the 510-830 nm wavelength range to condition the tissues in advance, making them more resistant to the harmful effects of reperfusion injury while maintaining the benefits of blood flow restoration.
2Object-affected harmful factors
If no light conditioning is applied, then the treatment procedure is simpler, but reperfusion injury is not reduced
Solution Approach 1:
The patent introduces an intermediary element - an optical fiber catheter - that delivers light energy to myocardial tissues. This intermediary enables tissue conditioning without requiring complex pharmacological interventions or surgical modifications, thereby reducing reperfusion injury while keeping the overall treatment approach relatively simple and minimally invasive.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces reperfusion injury in myocardial tissues by conditioning them with R/NIR light, improving tissue salvage and reducing the need for additional pharmacological agents.
Implementation Method 1
operating a light source coupled to a proximal end of the optical fiber catheter to generate light having at least one wavelength selected from a range of 510 nm to 830 nm. The light is communicated from the proximal end of the optical fiber catheter to its distal tip where the light is emitted from the optical fiber catheter
Data Source
AI summary
Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.