Optical Polarization Glucose Sensing Under Pressure Fluctuations
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Solution Overview
Problem
Conventional non-invasive blood glucose measurement techniques face challenges in accurately and sensitively measuring glucose levels due to significant fluctuations in bio-substance levels among diabetic patients, necessitating improved methods to enhance prediction accuracy.
Innovation Solution
A system utilizing a single polarization rotator with a 0-degree and rotating polarizer configuration, combined with a Mueller matrix analysis and Fourier expansion, processes optical feature data through a classification model to determine bio-substance concentration, addressing data imbalance and fluctuations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional non-invasive optical measurement techniques are used to measure blood glucose levels, then the measurement can be performed without skin puncture, but the measurement precision and sensitivity are insufficient due to significant fluctuations in bio-substance levels among diabetic patients
Solution Approach 1:
The patent employs a rotating polarizer that dynamically changes the polarization angle of incident light, allowing the system to capture optical features across multiple polarization states. This dynamic adjustment enables the extraction of more robust optical signatures that are less sensitive to fluctuations in bio-substance levels, thereby improving measurement precision and reliability simultaneously
Solution Approach 2:
The system varies multiple parameters including polarization angle, light wavelength, and detection timing to capture comprehensive optical feature data. By changing these parameters and analyzing the variations, the system can distinguish true glucose-related optical changes from noise caused by fluctuations in other bio-substances, enhancing both precision and reliability
2Device complexity
If a single polarization rotator system is used to simplify the device structure, then the device complexity is reduced, but the ability to capture comprehensive optical features may be compromised
Solution Approach 1:
The single polarization rotator performs periodic rotation to sequentially present different polarization angles to the incident light. This periodic action allows the system to capture optical features across the full polarization spectrum using one component, maintaining data completeness while avoiding the complexity of multiple simultaneous polarization devices
Solution Approach 2:
The rotating polarizer continuously modulates the polarization state of light throughout its rotation cycle, ensuring that all polarization angles are sampled over time. This continuous useful action from a single component achieves the same information gathering capability as multiple static polarizers would provide, preventing loss of optical feature information
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves precise and stable non-invasive glucose monitoring by effectively capturing optical features and compensating for pressure-induced fluctuations, demonstrating high prediction accuracy and stability in both phantom and human experiments.
Implementation Method 1
an incident polarizer set, positioned on an incident light optical path of the incident light, and being configured of a 0-degree polarizer and a rotating polarizer in a sequential manner
Implementation Method 2
a processor, signally connected to the light source generator and the optical reader, and being configured to run an optical feature analysis model to extract an optical feature information from the reflect light and to determine a concentration value of a bio-substance in the target area according to the optical feature information
Data Source
AI summary
The present invention discloses a system for non-invasive optical measurement of bio-substance in a biological tissue, comprising: a light source generator to generate an incident light to irradiate at a target area on an individual; an optical reader to receive a reflect light returning from the target area; and a processor to run an optical feature analysis model to extract an optical feature information from the reflect light and determine a concentration value of a bio-substance in the target area according to the optical feature information. With analysis based on optical rotation angles and light intensity signals, in combination of pressure effects and time delay compensation, effective features can be selected as input to the optical feature analysis model to improve the accuracy bio-substance level detection.