Optical HbA1c Detection Using Multi-Wavelength Blood Response
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Solution Overview
Problem
Existing blood component detection methods, particularly for glycated hemoglobin, are invasive, costly, time-consuming, and require complex apparatuses, and existing spectral detection methods fail to individually detect glycated hemoglobin effectively.
Innovation Solution
A glycated hemoglobin percentage detection method using optical response information at multiple wavelengths, including normalization and correction processes, to determine glycated hemoglobin percentage using common ultraviolet and visible light ranges, simplifying the detection process and reducing calculation requirements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional blood component detection methods (immunoturbidimetric method, HPLC, enzymatic method) are used to detect glycated hemoglobin, then measurement precision is improved, but device complexity, cost, and processing time increase significantly
Solution Approach 1:
The patent replaces complex mechanical/chemical detection systems (HPLC, immunoturbidimetric method) with an optical detection system using light sources and photodetectors. The method uses optical absorption spectra at multiple wavelengths to identify and quantify glycated hemoglobin, substituting mechanical separation and chemical reaction-based methods with non-invasive optical measurement.
Solution Approach 2:
The patent changes the detection parameter from requiring complex chemical reactions to measuring optical absorption characteristics at specific wavelengths. By identifying characteristic wavelength ranges where glycated hemoglobin exhibits unique absorption properties, the method transforms the detection approach into a simpler optical parameter measurement that can be performed with basic light sources and detectors.
2Measurement precision
If traditional glycated hemoglobin detection methods are used, then measurement precision is improved, but processing time and cost increase
Solution Approach 1:
The patent replaces time-consuming mechanical separation processes (HPLC) and complex chemical reactions (enzymatic method) with immediate optical measurement. The optical detection system provides real-time or near-real-time results by measuring light absorption without requiring sample preparation, separation, or incubation steps.
3Adaptability or versatility
If spectral information detection using oxygenated and deoxygenated protein concentrations is used, then detection capability is improved, but the ability to individually detect glycated hemoglobin is lost
Solution Approach 1:
The patent segments the spectral detection approach by identifying and analyzing specific wavelength ranges that are characteristic of glycated hemoglobin. Instead of using broad spectral information from oxygenated and deoxygenated proteins, the method focuses on segmented wavelength regions where glycated hemoglobin exhibits unique absorption features, enabling individual detection while maintaining spectral analysis capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method and electronic device enable non-invasive, cost-effective detection of glycated hemoglobin by utilizing common light wavelengths, significantly reducing complexity and calculation needs.
Implementation Method 1
a first wavelength light source providing circuit, a second wavelength light source providing circuit, a third wavelength light source providing circuit
Implementation Method 2
obtaining optical response information of a blood under test; performing a normalization and correction process based on the optical response information of the blood under test
Data Source
AI summary
A glycated hemoglobin percentage detection method includes: obtaining optical response information of a blood under test; performing a normalization and correction process based on the optical response information of the blood under test of a first wavelength to obtain normalized optical response information of the blood under test; selecting normalized optical response information of a second wavelength and normalized optical response information of a third wavelength from the normalized optical response information of the blood under test for analysis to determine a glycated hemoglobin percentage in the blood under test.