Non-invasive Hemoglobin Detection via Optical Finger Clip

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Solution Overview

Problem

Current methods for anemia detection in developing nations are inadequate due to reliance on invasive, subjective, and costly techniques, limiting widespread screening and effective public health interventions for moderate to severe anemia, especially in pregnant women.

Innovation Solution

A non-invasive hemoglobin detection system using a mobile device with a finger clip sensor that emits light at specific wavelengths, measuring light absorption to estimate hemoglobin levels, and communicates results via a cellular network, enabling cost-effective and objective anemia screening by community health workers.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If invasive blood-based assays are used for hemoglobin detection, then measurement precision is improved, but ease of operation and acceptance deteriorate due to discomfort and infection risk

Engineering Contradiction:
Improvehemoglobin detection accuracyVSAvoiduser acceptance and comfort
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent replaces the mechanical/invasive blood sampling system with an optical detection system. A light source emits light through the finger tissue, and a photodetector measures the transmitted light intensity. The system calculates hemoglobin concentration based on light absorption characteristics without breaking the skin, thereby eliminating infection risk and discomfort while maintaining measurement capability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces light as an intermediary medium to detect hemoglobin levels. Instead of directly contacting blood, the system uses light transmission through tissue as an intermediate step to infer hemoglobin concentration, making the measurement process non-invasive and more acceptable to users.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of operation

If non-invasive pallor test is used for anemia screening, then ease of operation is improved, but measurement precision deteriorates due to subjective judgment

Engineering Contradiction:
Improvescreening accessibilityVSAvoidanemia detection accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The patent replaces the subjective visual assessment method with an objective optical measurement system. Instead of relying on healthcare worker judgment of conjunctiva color, the system uses quantitative light absorption measurements at specific wavelengths to calculate hemoglobin concentration, eliminating subjectivity while maintaining ease of use.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system incorporates feedback through digital display of hemoglobin levels and automated calculation algorithms. The photodetector signals are processed by a microcontroller that applies calibration curves and algorithms to provide objective, quantifiable results with feedback to the user, removing reliance on subjective human judgment.

Inventive Principle:
Principle #23Feedback

3Measurement precision

If WHO color scale method is used for hemoglobin detection, then measurement precision is partially improved, but device complexity and cost increase due to special paper and controlled conditions

Engineering Contradiction:
Improvehemoglobin measurement accuracyVSAvoidtesting equipment requirements
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent extracts the essential measurement function from the complex WHO color scale system. Instead of requiring special color comparison paper, controlled environmental conditions, and multiple components, the system isolates the core function of light absorption measurement and implements it through a simple finger clip device with integrated light source and photodetector, reducing complexity while maintaining precision.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent merges the light source, photodetector, processing electronics, and display into a single integrated finger clip device. This consolidation eliminates the need for separate components like special paper, reference swatches, and environmental controls, simplifying the overall system while preserving measurement accuracy.

Inventive Principle:
Principle #5Merging (Combining)

4Measurement precision

If pulse oximetry based hemoglobin meters are used, then measurement precision is improved, but device complexity and cost increase making them unsuitable for developing nations

Engineering Contradiction:
Improvehemoglobin detection accuracyVSAvoidsystem complexity and cost
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent employs inexpensive, simple components that can be mass-produced at low cost. The finger clip uses basic LEDs, simple photodetectors, and minimal electronics that can be manufactured cheaply and disposed of or replaced easily, making the system economically viable for developing nations while maintaining adequate measurement precision for screening purposes.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent simplifies the optical system by using basic LED light sources and simple photodetector circuits instead of complex pulse oximetry systems. The measurement principle remains based on light absorption, but the implementation uses simpler, cheaper components that reduce device complexity and cost while maintaining functionality for hemoglobin screening.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system provides accurate, objective, and cost-effective anemia screening, facilitating targeted public health interventions and resource allocation, improving compliance and accountability of anemia programs, especially in remote areas.

Implementation Method 1

a light emitting diode (LED) configured to transmit light through tissue of the subject at four wavelengths

Methodology Applied
Scientific EffectLight emitting diode: Light Emitting Diode

Implementation Method 2

measure light absorption to estimate hemoglobin levels

Methodology Applied
Scientific EffectLight absorption: Absorption (EM radiation)

Implementation Method 3

A photosensor is configured to receive and measure light transmitted through the tissue of the subject by the LED

Methodology Applied
Scientific EffectPhotosensor: Photoelectric Effect

Data Source

PatentUS10918280B2Non-invasive bio-fluid detector and portable sensor-transmitter-receiver system
Publication Date: 2021.02.16 JOHNS HOPKINS UNIVERSITY
  • US10918280B2 patent drawing
  • US10918280B2 patent drawing
  • US10918280B2 patent drawing

AI summary

The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones.