Optical Property Reconstruction Without Instrument Response Calibration
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Solution Overview
Problem
Current methods for reconstructing optical properties of media in medical imaging, such as diffusion imaging, require lengthy experimental measurements to determine the instrument response, which is time-consuming and tedious.
Innovation Solution
A reconstruction method and system that reconstructs optical properties like absorption, scattering, and fluorescence properties without the need for experimental determination of the instrument response, using a reference medium and a characterization medium with known optical characteristics to calculate corrected signals and Green's functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If experimental measurements are performed to determine the instrument response for each source-detector pair, then the accuracy of optical property reconstruction is improved, but the measurement time and operational complexity increase significantly
Solution Approach 1:
The patent applies preliminary action by pre-calculating the instrument response function using a mathematical model that incorporates the known temporal distributions of the source function and detector response. This pre-computed instrument response is then reused for all source-detector pairs without requiring individual experimental measurements, thereby eliminating time-consuming repeated measurements while maintaining reconstruction accuracy
Solution Approach 2:
The patent uses copying by creating a mathematical model (copy) of the instrument response based on the source function and detector characteristics. This modeled copy replaces the need for physical experimental measurements for each source-detector pair, significantly reducing measurement time while preserving the essential information needed for accurate optical property reconstruction
2Measurement precision
If experimental measurements are performed to determine the instrument response for each source-detector pair, then the accuracy of optical property reconstruction is improved, but the operational complexity and tediousness increase
Solution Approach 1:
The patent replaces the mechanical experimental measurement system with a mathematical modeling approach. Instead of performing physical measurements for each source-detector pair, the instrument response is calculated using mathematical models of the source function and detector response, thereby eliminating the tedious and complex experimental procedures while maintaining measurement accuracy
Solution Approach 2:
The patent applies self-service by enabling the system to determine its own instrument response characteristics through mathematical modeling of its components (source and detector) rather than requiring external experimental calibration for each configuration. The system uses its known parameters to self-determine the instrument response, reducing operational complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the reconstruction of optical properties in two or three dimensions without requiring experimental determination of the instrument response, reducing measurement time and complexity.
Implementation Method 1
The method aims to locate one or more fluorophores contained in a scattering medium by illuminating the scattering medium with a radiation source and detecting, for at least one detector, the signal emitted by the medium at the fluorescence wavelength
Implementation Method 2
A temporal distribution of the signal received by the detector is then performed for each source-detector pair. This temporal distribution depends in particular on the values of the mean response time of the source function Ts and the mean response time of the detector Td
Data Source
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AI summary
The method involves establishing distribution of a signal received by a detector for a reference medium, and determining a modeling function (110) of a light scattering signal between a radiation source and the detector in the reference medium. Another distribution of another signal received by the detector is established for a medium to be characterized, where the received signal is emitted by the medium to be characterized following the illumination (120) of the medium by the source. A corrected signal is calculated (140) as a function of the modeling function and the latter distribution. The detector is a time-correlated single photon counting (TCSPC)-type device. An independent claim is also included for a reconstruction system.