Optical Sensor Noble Metal Layer Gamma Radiation Protection

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Solution Overview

Problem

Optical sensors used in medical and biotechnological applications are susceptible to damage from gamma radiation during sterilization, leading to reduced sensitivity and signal-to-noise ratio due to photobleaching and interaction with external light, particularly in hydrophilic matrices.

Innovation Solution

A three-layer optical sensor design featuring a transparent carrier, a porous hydrophilic matrix with a fluorescent dye, and a noble metal layer applied via vapor deposition, providing optical insulation and protection against external light and radiation, while maintaining contact with the measuring medium.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If gamma radiation sterilization is applied to optical sensors, then sterilization effectiveness is improved, but sensor sensitivity and signal-to-noise ratio deteriorate due to photobleaching and radiation damage

Engineering Contradiction:
Improvesterilization effectivenessVSAvoidsensor sensitivity
Core Design Contradiction:
ReliabilityVSMeasurement precision

Solution Approach 1:

A noble metal layer (silver, gold, or platinum) is applied as an intermediary protective barrier between the gamma radiation and the fluorescent dye in the hydrophilic matrix. This metallic coating absorbs or reflects the harmful radiation before it reaches the fluorescent dye, preventing photobleaching and sensitivity loss while allowing the sensor to undergo gamma sterilization. The noble metal layer acts as a shield that mediates the interaction between radiation and the sensitive fluorescent components.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If external light protection is enhanced for fluorescent sensors, then measurement precision is improved, but device complexity increases due to additional protective layers

Engineering Contradiction:
Improvesignal-to-noise ratioVSAvoidsensor structure
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The noble metal layer serves multiple functions simultaneously: it blocks external light to prevent interference with fluorescence measurements, protects against gamma radiation during sterilization, and provides a stable substrate for the hydrophilic matrix. By combining light shielding, radiation protection, and structural support in a single layer, the design achieves enhanced measurement precision without proportionally increasing device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The noble metal layer significantly reduces sensitivity to external light and radiation, enhancing the signal-to-noise ratio and maintaining sensor functionality during sterilization, with improved durability and cost-effectiveness.

Implementation Method 1

The metallic coating reflects the light from the light source as well as fluorescence generated by the sensor so that substantially no light reaches the sample

Methodology Applied
Scientific EffectReflection: Reflection

Implementation Method 2

The noble metal layer significantly reduces sensitivity to external light and radiation

Methodology Applied
Scientific EffectAbsorption (EM radiation): Absorption (EM radiation)

Implementation Method 3

a noble metal layer applied via vapor deposition

Methodology Applied
Scientific EffectPhysical Vapour Deposition: Physical Vapour Deposition

Implementation Method 4

a matrix which contains at least one fluorescent dye

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentEP2386058B1Optical sensor, device having the same, and method for producing the same
Publication Date: 2016.04.27 SARTORIUS STEDIM BIOTECH GMBH

AI summary

The present invention relates to an optical sensor. For known optical sensors, photo bleaching of the fluorescent dyes used often occurs. Said sensors are also sensitive to radiation products. The sensor according to the invention has a lower sensitivity to outside light influences, fluorophores, and radiation, in particular gamma radiation. The sensor according to the invention is suitable for determining at least one parameter in a medium. It comprises a matrix comprising a fluorescent dye. The matrix is carried on a transparent carrier. On the side facing the medium, the matrix comprises a noble metal layer providing protection against photo bleaching and radiation. The optical sensor is suitable for implementing in tanks and lab products that are sterilized using gamma radiation, such as single-use bioreactors.