Light-Scattering Particle Sizing for Accurate Optical Modulus Estimation

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Solution Overview

Problem

Existing methods for determining viscoelastic modulus using Laser Speckle Rheology (LSR) neglect the influence of particle size, leading to inaccurate characterization of materials, particularly in biological fluids and industrial polymers.

Innovation Solution

A system and method that determines the average size of light-scattering particles within a material by analyzing the azimuth-angle dependence of diffuse reflectance profiles, using a single optical system to improve the accuracy of viscoelastic modulus estimation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If particle size is neglected in LSR analysis, then the measurement process remains simple and quick, but the accuracy of viscoelastic modulus estimation deteriorates

Engineering Contradiction:
Improveviscoelastic modulus estimation accuracyVSAvoidmeasurement process complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines particle size determination and viscoelastic modulus measurement into a single integrated LSR analysis process. Both parameters are extracted simultaneously from the same speckle pattern data through mathematical modeling, eliminating the need for separate measurement procedures and additional equipment.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The LSR system is enhanced to perform multiple functions: it simultaneously characterizes both particle size and viscoelastic properties from the same optical measurements. The mathematical framework allows extraction of multiple material parameters from a single experimental setup and data set.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If particle size is taken into account, then the accuracy of material characterization is improved, but the complexity of analysis increases

Engineering Contradiction:
Improvematerial characterization accuracyVSAvoidanalysis complexity
Core Design Contradiction:
Measurement precisionVSDifficulty of detecting and measuring

Solution Approach 1:

The patent develops and applies a mathematical model that accounts for particle size effects in advance of actual measurements. Pre-computed lookup tables and calibration curves are generated based on theoretical considerations, allowing direct extraction of accurate results during experimental analysis without complex real-time calculations.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent replaces complex mechanical analysis with optical measurement and mathematical modeling. By using light scattering patterns and computational algorithms, the system achieves accurate material characterization without requiring complex mechanical testing apparatus or procedures.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Measurement precision

If additional measurements are performed to determine particle size, then accuracy is improved, but the measurement time increases

Engineering Contradiction:
Improveparticle size and viscoelastic accuracyVSAvoidmeasurement time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent merges particle size determination and viscoelastic modulus measurement into a single simultaneous process. Both parameters are extracted from the same speckle pattern data collected during one measurement session, eliminating the need for sequential measurements and reducing total analysis time.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The LSR system automatically extracts both particle size and viscoelastic properties from the measured data through built-in mathematical algorithms. The system performs self-characterization without requiring additional external measurements or separate analytical procedures, making the process efficient and self-contained.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Accurately quantifies viscoelastic properties by integrating particle size determination into the LSR process, enhancing precision and accuracy without requiring additional measurements or interrupting the LSR procedure.

Implementation Method 1

analysis of electromagnetic radiation that has interacted with the sample... analyzing the azimuth-angle dependence of diffuse reflectance profiles... size of light-scattering particles

Methodology Applied
Scientific EffectLight scattering: Scattering

Data Source

PatentEP4235151B1System and methods for estimation of mechanical properties and size of light-scattering particles in materials
Publication Date: 2025.08.27 THE GENERAL HOSPITAL CORP
  • EP4235151B1 patent drawingFigure 1
  • EP4235151B1 patent drawingFigure 2A~2D
  • EP4235151B1 patent drawingFigure 2E~2F

AI summary

System and method for determining a viscoelastic modulus of a sample using optical data acquired with an optical data acquisition portion including an optical detector configured to receive light, that has been delivered to the sample by an optical illumination portion and that has interacted with the sample, the optical data representing time evolution of a speckle associated with light-scattering particles of the sample, whereby an average size of the light-scattering particles is determined based on an angle-dependent pattern of a diffuse remittance profile (DRP) derived from the optical data, and a value of mean square displacement (MSD) of said light-scattering particles and the viscoelastic modulus of the sample is calculated from the acquired optical data, said MSD being a function of said size.