Opto-Fluidic Instrument Vibration Isolation for Stable Imaging

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Solution Overview

Problem

Opto-fluidic instruments face challenges in accurately analyzing biological samples due to internal and external vibrations, which cause distortions in image capture and processing errors, necessitating effective vibration mitigation techniques.

Innovation Solution

The system comprises a cooling system, an optics module with an optical frame and X-Y stage, and a chassis coupled to a vibration isolation device, with carefully tuned resonance frequency ranges to isolate and dampen vibrations, ensuring the X-Y stage experiences minimal displacement amplitude.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If the cooling system operates to maintain system temperature, then thermal management is improved, but internal vibrations are generated that cause image capture distortions and processing errors

Engineering Contradiction:
Improvesystem temperatureVSAvoidinternal vibrations
Core Design Contradiction:
TemperatureVSObject-affected harmful factors

Solution Approach 1:

The system is divided into separate vibration isolation zones: the chassis vibration isolation device isolates the main chassis from external vibrations, while the optical frame vibration isolation device isolates the optics module from chassis vibrations. This segmentation allows the cooling system to operate without transmitting vibrations to sensitive components.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Vibration isolation devices are introduced as intermediary elements between the cooling system and sensitive components. These devices (mounts, isolators, or dampers) act as mediators that allow thermal management while blocking vibration transmission, resolving the contradiction between temperature control and vibration generation.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Strength

If the optics module is mounted on the chassis, then structural support is improved, but vibrations from the chassis are transmitted to the optical components causing image distortions

Engineering Contradiction:
Improvestructural supportVSAvoidchassis vibrations
Core Design Contradiction:
StrengthVSObject-affected harmful factors

Solution Approach 1:

An optical frame with its own vibration isolation device is introduced as an intermediary between the chassis and the optics module. This intermediate structure provides the necessary structural support while the vibration isolation device prevents chassis vibrations from being transmitted to the sensitive optical components.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The mounting structure is segmented into two independent vibration isolation systems: chassis vibration isolation for the main structure and optical frame vibration isolation for the sensitive components. This allows each level to be optimized for its specific function while preventing vibration transmission.

Inventive Principle:
Principle #1Segmentation

3Ease of operation

If the X-Y stage is mounted on the optical frame, then positioning capability is improved, but vibrations cause the stage to exceed threshold displacement amplitudes

Engineering Contradiction:
Improvepositioning capabilityVSAvoidstage displacement accuracy
Core Design Contradiction:
Ease of operationVSManufacturing precision

Solution Approach 1:

The positioning system is segmented into independent vibration isolation levels, with the optical frame and its vibration isolation device separating the X-Y stage from chassis vibrations. This ensures the stage operates in a vibration-minimized environment while maintaining full positioning capability.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Vibration isolation devices are installed beforehand in the optical frame to cushion and dampen vibrations before they can affect the X-Y stage. This preemptive cushioning ensures the stage remains within threshold displacement amplitudes during operation.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

4Object-affected harmful factors

If vibration isolation devices are added to the system, then vibration mitigation is improved, but device complexity increases

Engineering Contradiction:
Improvevibration isolationVSAvoidsystem structure
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The vibration isolation system is segmented into two independent, modular units: chassis vibration isolation and optical frame vibration isolation. This modular segmentation makes the complex system easier to design, install, and maintain while achieving comprehensive vibration mitigation.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration effectively reduces vibrational displacement amplitudes to below threshold levels, maintaining image accuracy and system stability during sample analysis, even in environments prone to external vibrations.

Implementation Method 1

the optical frame having a first resonance frequency within a first resonance frequency range (RFR)... the chassis vibration isolation device having a second resonance frequency within a second RFR

Methodology Applied
Scientific EffectResonance frequency separation: Resonance

Implementation Method 2

the cooling system is configured to vibrate at one or more frequencies within a vibrational frequency range (VFR) when the system is in operation

Methodology Applied
Scientific EffectMechanical vibration: Vibration

Data Source

PatentUS20240159292A1Systems and methods for mitigating vibrations
Publication Date: 2024.05.16 10X GENOMICS INC
  • US20240159292A1 patent drawing
  • US20240159292A1 patent drawing
  • US20240159292A1 patent drawing

AI summary

Various embodiments of the present disclosure disclose mitigating internal and external vibrational disturbances in opto-fluidic instrument. In various embodiments, the resonance frequency ranges and/or the vibrational frequency ranges of various modules and components of the opto-fluidic instrument may be selected to avoid resonances from occurring in the opto-fluidic instrument, thereby mitigating vibrations from internal and external sources that may distort the imaging of samples in the opto-fluidic instrument.