Oral Adhesive Patch With Reticular Drug Layer

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Solution Overview

Problem

Conventional adhesive patches for the oral cavity, particularly for tooth whitening, face issues with residue left on the teeth and mucous membrane due to strong adhesion, and delamination between the drug layer and backing layer, especially under high temperature and aging conditions, leading to contamination and manufacturing complexities.

Innovation Solution

A patch design featuring a reticular structure within the drug layer, divided into two sections by the reticular structure, with a backing layer laminated to prevent delamination and facilitate easy removal, utilizing ethyl cellulose for the backing layer and water-soluble polymers for the drug layer, allowing controlled release of active ingredients through the reticular structure's through holes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If water-soluble polymers are used in the drug layer to ensure stability of hydrogen peroxide, then adhesion to oral cavity is improved, but residue on tooth surface increases significantly

Engineering Contradiction:

Improvestability of hydrogen peroxideVSAvoidresidue on tooth surface

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patch is divided into two distinct layers: a water-soluble drug layer containing hydrogen peroxide and water-soluble polymers for stability and adhesion, and a water-insoluble PE film backing layer for structural support. This segmentation allows the drug layer to provide necessary adhesion and stability while the backing layer prevents excessive residue by maintaining structural integrity during removal.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patch combines water-soluble polymers (for drug delivery and adhesion) with water-insoluble PE film (for structural stability). This composite structure enables the patch to maintain strong adhesion through the water-soluble components while the water-insoluble backing layer prevents excessive residue by providing a stable framework that facilitates clean removal.

Inventive Principle:

Principle #40Composite materials

2Strength

If PE film is used as backing layer to prevent breakage and enable customization, then flexibility and tensile strength are improved, but delamination between drug layer and backing layer occurs under high temperature and aging conditions

Engineering Contradiction:

Improvetensile strength and flexibilityVSAvoidbonding between drug layer and backing layer

Core Design Contradiction:

StrengthVSStability of the object's composition

Solution Approach 1:

The patent optimizes the thickness of the PE film backing layer to 10-50 μm and controls the coating amount of the drug layer to 1-10 mg/cm². These parameter adjustments ensure that the backing layer provides sufficient tensile strength and flexibility while maintaining proper bonding with the drug layer, preventing delamination under high temperature and aging conditions.

Inventive Principle:

Principle #35Parameter changes

3Duration of action of moving object

If strong adhesion is achieved to ensure long-term efficacy, then duration of action is improved, but ease of removal deteriorates due to excessive residue

Engineering Contradiction:

Improvelong-term efficacyVSAvoidease of removal

Core Design Contradiction:

Duration of action of moving objectVSEase of operation

Solution Approach 1:

The patch is segmented into a water-soluble drug layer that provides strong adhesion for long-term efficacy and a water-insoluble PE film backing layer that facilitates easy removal. The water-soluble components ensure prolonged contact and drug delivery, while the water-insoluble backing layer maintains structural integrity for clean removal without excessive residue.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patch is designed as a disposable product where the water-soluble drug layer is consumed during the treatment period to provide long-term efficacy, while the water-insoluble PE film backing layer serves as a temporary support structure that is removed after use, leaving minimal residue.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The patch provides excellent adhesion and usability, minimizing residue upon removal, preventing delamination and breakage, and maintaining stability under various conditions, ensuring effective delivery of active ingredients while allowing neat removal without excessive material left on the teeth or oral cavity.

Implementation Method 1

Conventional patch products contain water-soluble polymers having good adhesion to teeth and/or oral tissue

Methodology Applied

Scientific EffectAdhesion: Adhesive

Implementation Method 2

allowing controlled release of active ingredients through the reticular structure's through holes

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 3

when the drug layer in the patch is hydrated by moisture such as saliva

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS11547640B2Adhesive patch to oral cavity having improved stability and usability

Publication Date: 2023.01.10 LG HOUSEHOLD & HEALTH CARE LTD

AI summary

The present disclosure provides a patch which is attached to a tooth or oral mucous membrane and releases an active ingredient to a portion attached, in which the patch comprises a drug layer having an adhesive surface attached to the tooth or oral mucous membrane and a backing layer laminated on the drug layer, and comprises at least one reticular structure inside the drug layer, and is divided into at least 2 drug layers at the boundary of or by the reticular structure.