Oral Care Compositions Using Polyamine Stabilizers

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Solution Overview

Problem

Existing oral care compositions face challenges in delivering effective levels of cationic antibacterial agents while preventing staining and biofilm formation, as these agents often precipitate with anionic polymers in aqueous formulations, reducing their efficacy.

Innovation Solution

Incorporating a stabilizing amount of an orally acceptable polyamine compound, such as lysine, into formulations with anionic polymers and cationic antibacterial agents creates a biphasic system that enhances the delivery of cationic agents by preventing precipitation and maintaining their availability for interaction with bacteria.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If cationic antibacterial agents are combined with anionic polymers in aqueous formulations, then staining and biofilm formation are prevented, but the cationic agents precipitate and their efficacy is reduced

Engineering Contradiction:

Improvestaining and biofilm formationVSAvoidantibacterial efficacy

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

A nonionic polymer is introduced as an intermediary substance that is compatible with both cationic antibacterial agents and anionic polymers. This mediator prevents direct interaction between the incompatible cationic and anionic components, allowing all three ingredients to coexist in the same aqueous formulation without precipitation while maintaining their individual functions

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The formulation creates a composite system combining cationic antibacterial agents, anionic polymers, and nonionic polymers in a single aqueous phase. This composite approach allows the incompatible components to work together synergistically, with the nonionic polymer serving as a compatibility enhancer that enables the composite formulation to achieve both stain prevention and antibacterial efficacy

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach improves the local concentration and delivery of cationic agents to the teeth, effectively inhibiting staining and biofilm formation while maintaining the antibacterial efficacy of the agents.

Implementation Method 1

Methodology Applied

Scientific EffectBiphasic system formation: Phase Change

Data Source

PatentUS12257334B2Oral care compositions

Publication Date: 2025.03.25 COLGATE PALMOLIVE CO

AI summary

This application provides, among other things, novel aqueous oral care compositions useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with anionic polymers that protect against erosion and staining, by addition of a stabilizing amount of a polyamine, e.g., lysine, and methods for making and using the same.