Oral Care Tin Stabilization With Monodentate and Polydentate Ligands
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Solution Overview
Problem
Oral care compositions face challenges in stabilizing tin ions due to reactivity with other components, leading to reduced availability and efficacy, as under-stabilization or over-stabilization can result in lower bioavailability of tin ions, affecting dental health benefits.
Innovation Solution
The use of specific molar ratios of tin, monodentate ligands, and polydentate ligands, such as carboxylic acids and polyphosphates, to stabilize tin ions, ensuring optimal bioavailability and fluoride uptake, thereby maintaining oral care benefits over the composition's shelf-life.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If tin is under-stabilized in oral care compositions, then tin can react with other components (such as silica, water), but this leads to lower amount of available tin ions
Solution Approach 1:
The patent applies parameter changes by optimizing the molar ratio of chelant to tin within specific ranges (0.5:1 to 5:1, preferably 1:1 to 3:1) and controlling pH levels (6.0-8.0) to achieve the right balance between tin stabilization and bioavailability. This resolves the contradiction by finding optimal parameter values that prevent both under-stabilization and over-stabilization
Solution Approach 2:
The patent uses composite chelating systems combining multiple chelating agents (such as citrate, gluconate, phosphate, and fluoride) working together with tin ions. This composite approach provides synergistic stabilization while maintaining appropriate tin ion availability, resolving the contradiction between stability and bioavailability
2Stability of the object's composition
If tin is over-stabilized or chelant-tin interaction is too strong, then tin ions are tied up when delivered to oral cavity, but this also leads to lower amount of bioavailable tin ions
Solution Approach 1:
The patent controls the strength of chelant-tin interaction by selecting specific chelating agents with appropriate binding affinities and optimizing their concentrations within defined molar ratios. This ensures tin remains stabilized during storage but releases adequate bioavailable ions in the oral cavity
Solution Approach 2:
The patent introduces fluoride ions as intermediaries that mediate between the chelated tin complex and the oral surfaces. Fluoride acts as a bridge that facilitates controlled release of tin ions while maintaining stability, resolving the contradiction between strong binding and bioavailability
3Stability of the object's composition
If tin reacts with other components of oral care composition, then stability is affected, but this also reduces amount of available tin ions for desired benefit
Solution Approach 1:
The patent introduces chelating agents as intermediary substances that selectively bind to tin ions, protecting them from reacting with other composition components like silica and water. This intermediary chelation maintains both composition stability and tin ion availability simultaneously
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The optimized ligand ratios provide unexpectedly high soluble tin amounts and fluoride uptake, enhancing dental health benefits while preventing interference with other oral care ingredients.
Implementation Method 1
The oral care composition comprises (a) tin; (b) monodentate ligand; and (c) polydentate ligand, wherein the oral care composition has a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5
Data Source
AI summary
Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.