Oral Composition with Baobab and Alginate for Dual-Phase Release
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Solution Overview
Problem
Current oral compositions for human or animal administration fail to optimally control delivery and bioavailability, particularly for active ingredients requiring two release phases: immediate and modified release phases, as seen in melatonin administration for improved sleep quality.
Innovation Solution
A composition comprising baobab extract, alginate, and an impregnated powder with a concentrated plant extract, formulated into multilayer tablets, which provides a controlled release of active ingredients, achieving an immediate release phase within 1-30 minutes and a prolonged, delayed phase of 3-5 hours.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional oral compositions are used, then administration is simple, but delivery control and bioavailability are not optimal
Solution Approach 1:
The composition is divided into multiple functional components (baobab extract, alginate, impregnated powder) that each contribute to different aspects of drug release. This segmentation allows independent optimization of immediate and modified release phases without complicating the overall formulation approach.
Solution Approach 2:
The invention uses a composite formulation combining baobab extract (providing immediate release), alginate (forming gel matrix for modified release), and impregnated powder (containing concentrated plant extract). This composite approach enables dual-phase release while maintaining formulation simplicity.
2Duration of action of moving object
If single-phase release is used, then composition is simple, but two release phases (immediate and modified) are not achieved
Solution Approach 1:
The composition dynamically transitions from immediate release (baobab extract phase) to modified release (alginate gel phase) over time. This dynamic behavior provides extended duration of action without requiring complex mechanical switching mechanisms.
Solution Approach 2:
The release mechanism exploits changes in physical-chemical parameters over time, specifically the hydration and gelation of alginate in the gastrointestinal tract. This parameter change drives the transition from immediate to modified release phases without additional complexity.
3Speed
If rapid release is achieved, then onset is fast, but prolonged action is reduced
Solution Approach 1:
The total drug load is segmented between immediate-release and modified-release components. The baobab extract portion provides rapid onset, while the alginate-impregnated powder portion ensures prolonged action, resolving the trade-off between speed and duration.
Solution Approach 2:
The invention merges immediate release and modified release mechanisms into a single integrated formulation. Both release phases occur from one composition, allowing simultaneous achievement of fast onset and prolonged action without requiring multiple separate administrations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively achieves two successive release phases, enhancing the bioavailability and duration of melatonin, ensuring rapid onset and prolonged action, thereby improving sleep quality and reducing nighttime awakenings.
Implementation Method 1
alginate
Implementation Method 2
a modified release phase, preferably prolonged, delayed and advantageously matrix-effect
Implementation Method 3
an impregnated powder, comprising a plant support on which is fixed a concentrated plant extract
Data Source
Figure 1~2
Figure 3~4
AI summary
The present invention relates to a composition intended for administration to a human or animal subject, advantageously by oral route. This composition comprises at least the following components: - a baobab extract, - alginate, - an impregnated powder, comprising a plant carrier to which a concentrated plant extract is fixed, and - at least one active ingredient.