Oral Drug Filter Structure for Low Resistance and Granule Retention
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Solution Overview
Problem
Existing drug accommodating devices face challenges in balancing low liquid resistance and preventing leakage of drug granules or multi-particulates, particularly those with particle sizes smaller than the pore diameter, leading to reduced applicability and increased costs.
Innovation Solution
A drug accommodating apparatus with a filtering component featuring intricately crossed pore channels and a water-soluble polymer material layer to prevent leakage while maintaining low liquid resistance, using materials like polypropylene and polyvinylidene fluoride for the filter membrane and supporting components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the pore diameter of the drug accommodating component is made large, then the resistance of liquid passing is reduced, but the probability of leakage of granules or multi-particulates with smaller particle sizes increases
Solution Approach 1:
The invention transitions from a single-layer flat filter membrane to a multi-layer stacked filter membrane structure. By adding the dimension of layer stacking with alternating orientations, the system achieves both large effective pore diameter (for low liquid resistance) and small effective leakage openings (by leveraging particle size distribution gaps between adjacent layers with different orientation angles).
Solution Approach 2:
Different regions of the filtering system have different functions: the first filter membrane layer has a first orientation angle optimized for capturing larger particles, while the second filter membrane layer has a second orientation angle optimized for capturing smaller particles. This local differentiation in orientation angles creates a staged filtering effect that addresses both liquid flow and particle retention requirements.
2Reliability
If the pore diameter is made small to prevent granule leakage, then liquid resistance increases, requiring artificial screening which reduces yield and increases cost
Solution Approach 1:
The invention uses multi-layer stacking with alternating orientations to create a three-dimensional filtering structure. This allows the use of larger pore diameters in each individual layer (improving manufacturing yield by eliminating the need for artificial screening) while the stacked configuration with different orientations prevents particle leakage through the combined effect of multiple filtering planes.
Solution Approach 2:
The filtering system combines multiple filter membrane layers with different orientation angles into a composite structure. This composite approach allows each layer to be manufactured with larger pores (improving yield) while the combination of layers creates an effective barrier against particle leakage, avoiding the need for expensive artificial screening processes.
3Device complexity
If a single-layer filter membrane is used, then the structure is simple, but it cannot effectively prevent leakage of granules with particle sizes smaller than the pore diameter
Solution Approach 1:
The filtering system is segmented into multiple filter membrane layers, each with a specific orientation angle. The first layer captures particles based on its orientation, while the second layer with a different orientation captures remaining smaller particles. This segmentation allows each layer to specialize in capturing particles of certain size ranges, improving overall separation effectiveness without requiring excessive complexity in any single layer.
Solution Approach 2:
By stacking filter membranes at different orientation angles, the system adds an angular dimension to the filtering process. This dimensional approach creates multiple filtering planes that intersect, effectively blocking particles of various sizes that would pass through a single-layer structure, thereby improving reliability without excessive complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures effective delivery of drug granules or multi-particulates with minimal leakage and resistance, suitable for a wide range of particle sizes, including those smaller than the pore diameter, enhancing device applicability and reducing costs.
Implementation Method 1
The filtering component is provided with a water-soluble polymer material layer, so that the drug granules or multi-particulates cannot pass through; and the water-soluble polymer material layer enables effective delivery with minimal leakage
Implementation Method 2
the filtering component has one or more pore channels allowing a liquid to pass; the pore channels are distributed in the filtering component in an up-down intricate intersection mode
Data Source
Figure 1a~3
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Figure 7a~9b
AI summary
A drug accommodating device of a solid oral formulation and an oral administration and delivery apparatus comprising same. The drug accommodating device comprises a filtering component and a supporting component; the filtering component and the supporting component cooperate with each other to form a space used for bearing drug particles or multiple pills; the filtering component has one or more pore channels allowing a liquid to pass; the pore channels are distributed in the filtering component in an up-down intricate intersection mode; alternatively, a water-soluble polymer material layer is provided on the filtering component. Alternatively, the drug accommodating device is a cylindrical structure with a top end being an opening and a bottom part being a screen mesh; the inner surface of the screen mesh is provided with the water-soluble polymer material layer; an inner cavity having the cylindrical structure above water-soluble polymer material layer is used for accommodating the drug particles or multiple pills. The drug accommodating device can overcome the problem that fluid resistance is large when the drug particles or multiple pills are leaked and sipped.