Oral Hydrogen-Generating Solid Forms for Viral Symptom Relief
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Solution Overview
Problem
Current methods for delivering molecular hydrogen for treating viral infections, such as the common cold and influenza, have limitations, including instability of hydrogen-infused liquids and the need for clinical settings for inhalation or injection, which restricts their accessibility and efficacy.
Innovation Solution
Development of oral, ingestible solid forms that generate molecular hydrogen in the gastrointestinal tract, such as capsules or tablets, which release hydrogen nanobubbles upon contact with gastric juice, providing a stable and self-administerable therapeutic option for boosting the immune response and alleviating symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If H2 inhalations or injections are used, then therapeutic effect is achieved, but accessibility is limited to clinical settings
Solution Approach 1:
The solid H2-generating forms are designed to be self-administered by the patient at home. The capsule contains magnesium carbonate and citric acid that automatically react with gastric acid to generate H2 nanobubbles without requiring clinical intervention, enabling patients to treat themselves in a self-service manner.
Solution Approach 2:
The invention replaces the mechanical/administrative system of clinical inhalation or injection with a chemical reaction system. The magnesium carbonate and citric acid undergo chemical reaction with gastric acid to produce H2 gas, eliminating the need for medical professionals to administer H2 therapy.
2Quantity of substance
If H2-infused liquids are used, then H2 delivery is achieved, but stability deteriorates due to quick hydrogen dissipation
Solution Approach 1:
The solid H2-generating forms are pre-formulated with magnesium carbonate and citric acid in a stable solid state. The H2 is generated on-demand through chemical reaction with gastric acid, rather than being pre-dissolved in liquid where it would quickly dissipate. This preliminary preparation in solid form ensures stability until activation.
Solution Approach 2:
The invention changes the physical state of hydrogen delivery from liquid (H2-infused water) to solid (capsule containing reactants). This parameter change from liquid to solid form fundamentally alters the stability issue, as the solid capsule remains stable until it reacts with gastric acid to generate H2 nanobubbles.
3Ease of operation
If solid H2-generating forms are administered, then ease of operation improves for self-administration, but manufacturing complexity increases
Solution Approach 1:
The capsule serves as an intermediary carrier that delivers the H2-generating chemistry to the gastrointestinal tract. Instead of manufacturing complex H2 delivery systems, the invention uses a simple capsule containing magnesium carbonate and citric acid as intermediaries that naturally react with gastric acid to produce H2.
Solution Approach 2:
The formulation is designed to be self-activating through the natural chemical reaction between magnesium carbonate, citric acid, and gastric acid. This self-service mechanism eliminates the need for complex manufacturing or administration systems, as the body's own gastric acid provides the activation trigger.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The oral hydrogen-generating solid forms effectively reduce the severity and duration of viral infection symptoms by enhancing the immune response and suppressing oxidative stress and inflammation, offering a safe and convenient treatment option for viral infections like the common cold and influenza.
Implementation Method 1
Basic and clinical research has revealed that H2 is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs
Implementation Method 2
Basic and clinical research has revealed that H2 is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs
Implementation Method 3
Hydrogen nanobubbles penetrate through the body tissues and blood, and provide therapeutic effect
Implementation Method 4
provide therapeutic effect such that boosting the subject's immune response to a viral infection
Data Source
AI summary
A method for alleviating, preventing or treating symptoms of a viral infection such as common cold and flu, comprising administering to a subject in need thereof at least one solid form that releases molecular hydrogen upon exposure to the subject's gastric juice.