Oral Microbiome Manipulation via Targeted Genetic Analysis
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Solution Overview
Problem
Current methods fail to effectively manipulate and modify the oral microbiome of mammals to improve oral health conditions, as they lack a systematic approach for analyzing microbial taxa and implementing interventions based on specific microbiome features.
Innovation Solution
The method involves analyzing genetic material from oral samples to identify microbiome features, such as taxonomic diversity and metabolic functions, and implementing interventions like probiotics, dietary modifications, and physical interventions to alter the oral microbiome balance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional oral health methods are used, then general oral hygiene is maintained, but the oral microbiome cannot be effectively manipulated to improve oral health conditions
Solution Approach 1:
The patent segments the complex microbiome manipulation task into distinct functional modules: sample collection devices, genetic material extraction systems, sequencing analysis platforms, and intervention delivery mechanisms. Each module handles a specific aspect of the process, making the overall system more manageable and implementable while achieving reliable microbiome modification
Solution Approach 2:
The patent performs preliminary sequencing and analysis of the oral microbiome before implementing interventions. By characterizing the baseline microbial composition and identifying specific taxa of interest in advance, the system can then target interventions precisely to modify the microbiome effectively, improving reliability without requiring complex real-time adjustments
2Measurement precision
If comprehensive microbiome analysis is performed, then targeted oral health interventions can be identified, but time and resources are consumed
Solution Approach 1:
The patent applies partial sequencing strategies where only specific genetic regions or selected microbial taxa are analyzed rather than performing complete genome sequencing of all microbes. This approach provides sufficient precision for identifying target interventions while significantly reducing analysis time and computational resources required
Solution Approach 2:
The patent focuses analysis and intervention efforts on specific local regions of the oral cavity (e.g., plaque, gingival crevicular fluid, saliva) rather than attempting to analyze all oral surfaces simultaneously. This localized approach maintains measurement precision for the target site while reducing overall time and resource consumption
Data Source
AI summary
This invention is directed to manipulation and modification of the oral microbiome of a mammal, in particular a companion mammal, by intervention, for example by administration of supplemental compounds, modification of a dietary component, and/or physical intervention, based on sampling and assessment of microbes. The methods can be for the purpose of potentially improving an oral health condition of the individual. Manipulations are based on analysis of at least one sample obtained from an oral tissue or oral cavity of the mammal, and optionally other mammals, each sample including or indicative of microbes of an oral microbiome.