Oral Polyphenols for Skin Photoprotection and Density
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Solution Overview
Problem
Exposure to environmental factors such as UV radiation and stress leads to deterioration in skin quality, including reduced hydration, thickness, and attractiveness, with existing methods failing to effectively address these issues.
Innovation Solution
Oral administration of polyphenolic compounds like epicatechin and catechin, or their pharmaceutically acceptable salts, in compositions such as cocoa components, to improve skin quality by enhancing hydration, thickness, and reducing roughness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral administration of polyphenolic compounds is performed, then skin photoprotection and quality improvement is achieved, but existing methods fail to effectively address UV radiation damage and skin deterioration
Solution Approach 1:
The patent applies preliminary action by administering polyphenolic compounds (epicatechin, catechin, and their salts) orally before UV radiation exposure to prevent skin damage. The compounds are absorbed systemically and provide photoprotective effects by neutralizing free radicals and reducing oxidative stress in the skin before UV damage occurs, thereby preventing rather than treating the harm.
Solution Approach 2:
The patent converts the harmful effect of UV radiation into a beneficial outcome by using polyphenolic compounds that specifically target and neutralize the damaging mechanisms of UV exposure. The compounds transform the oxidative stress and free radical damage caused by UV radiation into a controlled physiological response that enhances skin protection and improves skin quality parameters.
2Object-affected harmful factors
If environmental factors such as UV radiation and stress are exposed to, then skin quality deteriorates including reduced hydration, thickness, and attractiveness, but effective methods to counteract these effects are lacking
Solution Approach 1:
The patent uses polyphenolic compounds as intermediary substances that mediate between environmental harmful factors (UV radiation, stress) and skin tissue. These compounds act as free radical scavengers and antioxidants that intercept and neutralize the damaging effects before they reach and damage skin structures, thereby stabilizing skin quality parameters including hydration, thickness, and overall appearance.
Solution Approach 2:
The patent achieves stabilization of skin quality by changing the biochemical parameters of skin through polyphenolic compound administration. The compounds modify oxidative stress levels, free radical concentrations, and inflammatory markers, thereby maintaining stable skin hydration, thickness, and structural integrity despite environmental challenges.
Data Source
AI summary
This invention relates to compositions, and methods of use thereof, for (i) reducing ultraviolet (UV)-induced skin erythema and/or photoaging, and for (ii) improving skin quality, each method comprising orally administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.