Oral Probiotic Composition Using S. Salivarius G7 for Broad Pathogen Control

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Solution Overview

Problem

Existing oral probiotics fail to effectively address a wide range of harmful bacteria and fungi, leading to oral diseases such as gingivitis, periodontitis, dental caries, and halitosis, while also contributing to systemic health issues due to microbial imbalance.

Innovation Solution

A novel Streptococcus salivarius strain (S. salivarius G7, KCCM13161P) with enhanced antibacterial, antifungal, and anti-inflammatory properties is developed, which can inhibit a variety of pathogenic bacteria and fungi, including Aggregatibacter actinomycetemcomitans, Actinomyces israelii, Candida albicans, and others, and is formulated into oral compositions for disease prevention and alleviation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional oral probiotics are used, then some oral health benefits are provided, but they fail to effectively address a wide range of harmful bacteria and fungi

Engineering Contradiction:

Improvebroad-spectrum antibacterial and antifungal activityVSAvoideffectiveness against pathogenic bacteria

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent applies universality by developing a Streptococcus salivarius strain that performs multiple functions simultaneously: it produces bacteriocins for antibacterial activity, generates hydrogen peroxide for antifungal activity, and exhibits anti-inflammatory effects. This multi-functional probiotic strain can address various oral pathogens (including Gram-positive and Gram-negative bacteria and fungi) with a single agent, resolving the contradiction between broad adaptability and reliable effectiveness.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Object-affected harmful factors

If oral probiotics with strong antibacterial effects are developed, then harmful bacteria are suppressed, but the complexity of the probiotic formulation increases

Engineering Contradiction:

Improvesuppression of pathogenic bacteria and fungiVSAvoidprobiotic strain complexity

Core Design Contradiction:

Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent applies self-service by engineering the probiotic strain to autonomously produce multiple antimicrobial mechanisms (bacteriocin secretion, hydrogen peroxide generation) without requiring external formulation components. The strain self-regulates its antimicrobial activity through quorum sensing and environmental cues, simplifying the overall probiotic formulation while maintaining strong suppression of pathogenic bacteria and fungi.

Inventive Principle:

Principle #25Self-service

3Reliability

If a novel Streptococcus salivarius strain with enhanced activity is developed, then antibacterial and antifungal efficacy is improved, but the difficulty of strain isolation and characterization increases

Engineering Contradiction:

Improveantibacterial and antifungal activityVSAvoidstrain isolation and characterization

Core Design Contradiction:

ReliabilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent applies preliminary action by pre-screening and selecting candidate strains based on known beneficial traits (bacteriocin production capability, hydrogen peroxide generation potential) before full characterization. The strain isolation process uses targeted enrichment cultures and preliminary phenotypic screening to identify promising candidates, reducing the overall difficulty of characterizing the final high-efficacy strain while maintaining reliable antibacterial and antifungal activity.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The S. salivarius G7 strain demonstrates 4 to 8 times higher antibacterial activity and superior halitosis suppression compared to conventional strains, effectively preventing or alleviating oral diseases like gingivitis, periodontitis, dental caries, and halitosis through its broad-spectrum activity.

Implementation Method 1

These bacteria suppress neighboring bacteria by producing bacteriocin during the competition for habitats in bacteria. Streptococcus salivarius also produces various types of lantibiotics, such as salivaricin A, salivaricin B, salivaricin 9, and salivaricin G3216-18, which are similar to bacteriocin

Methodology Applied

Scientific EffectBacteriocin production:

Implementation Method 2

The S. salivarius G7 strain produces hydrogen peroxide and has antifungal activity

Methodology Applied

Scientific EffectHydrogen peroxide production:

Implementation Method 3

The S. salivarius G7 strain has antiinflammatory activity... it can inhibit the production of inflammatory mediators such as TNF-α, IL-6, and IL-8 in host cells

Methodology Applied

Scientific EffectAnti-inflammatory activity:

Data Source

PatentUS20260053868A1Method of using a composition comprising a novel streptococcus salivarius strain in preventing or alleviating an oral disease

Publication Date: 2026.02.26 GREENSTORE INC

AI summary

Disclosed are a novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain, a composition containing the same for prevention or alleviation of an oral disease, and oral probiotics, and specifically, the novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain can prevent, treat, and alleviate periodontal diseases through strong antibacterial and antiinflammatory activities against periodontal disease-causing strains, prevents, treat, and alleviates dental caries through strong antibacterial activity against dental caries-causing strains and biofilm formation inhibitory ability, and suppress halitosis caused by oral diseases, thereby contributing to oral health improvement.