Bioadhesive Oral Strips Modifying Microbiome to Prevent Alzheimer's
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Solution Overview
Problem
Current treatments for Alzheimer's disease are ineffective in reversing or preventing the progression of the disease, as they primarily focus on symptomatic relief without addressing the underlying cause, which is linked to oral microbiome imbalance and spirochetal infections.
Innovation Solution
The development of oral strips and compositions that modify the oral microbiome by introducing beneficial bacteria like Prevotella intermedia, reducing spirochete growth, and using antibiotics to target periodontal pathogens, while maintaining a healthy oral environment to prevent the spread of bacteria to the brain.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current Alzheimer's disease treatments are used, then symptomatic relief is provided, but the disease progression cannot be reversed or prevented
Solution Approach 1:
The patent applies preliminary action by treating the oral microbiome imbalance and spirochetal infections early in the disease process, before irreversible brain damage occurs. The method targets the root cause in the oral cavity to prevent the infection from spreading to the brain, thereby preventing Alzheimer's disease progression rather than merely treating symptoms after they appear.
2Object-affected harmful factors
If antibiotics are used to target periodontal pathogens, then spirochete growth is reduced, but oral microbiome balance may be disrupted
Solution Approach 1:
The patent applies local quality by using subantimicrobial dose doxycycline (SADD), which exerts its effect locally at the periodontal site through anti-collagenase and anti-inflammatory properties rather than systemic broad-spectrum antibacterial action. This localized approach targets pathogenic enzymes and inflammation without disrupting the overall oral microbiome balance.
Solution Approach 2:
The patent applies parameter changes by using doxycycline at subantimicrobial doses (lower concentrations than traditional antibiotic therapy). This parameter change in dosage transforms the drug's function from broad-spectrum bactericidal activity to localized anti-inflammatory and anti-collagenase activity, preserving microbiome balance while still treating the periodontal pathology.
3Reliability
If oral strips with beneficial bacteria are introduced, then oral microbiome is modified to prevent Alzheimer's, but device complexity increases
Solution Approach 1:
The patent applies the intermediary principle by using oral strips as a delivery vehicle that mediates between the beneficial bacteria (Prevotella intermedia) and the oral cavity environment. The strip serves as an intermediate carrier that introduces and maintains the beneficial bacteria at the target site, facilitating microbiome modification without requiring complex administration procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively reduces the likelihood of Alzheimer's disease progression by addressing the root cause of oral microbiome imbalance and spirochetal infections, potentially preventing the onset of the disease and its associated cognitive decline.
Implementation Method 1
introducing beneficial bacteria like Prevotella intermedia
Implementation Method 2
using antibiotics to target periodontal pathogens
Implementation Method 3
The first side has a bioadhesive that is adapted to bind to a portion of an individual's oral cavity for an extended period of time
Data Source
AI summary
A method and system of reducing the likelihood of a Porphyromonas gingivalis infection in a human being includes the use of a bioadhesive strip that binds to a person's mucosal membrane for at least 1 hour while inside a person's mouth, where the strip has a therapeutically effective amount of an anti-biofilm agent, compounds that facilitate the growth of desired bacteria beneficial to a person's health, and an antibiotic effective amount to kill Porphyromonas gingivalis bacteria. The method and system reduces the virulence factor gingipain. In other embodiments, the likelihood that a subject will suffer from Alzheimer's Disease is reduced by administering, via local gingival application to a subject that has been diagnosed with periodontitis, an effective amount of an antibiotic effective to kill Porphyromonas gingivalis bacteria residing on the subgingival tooth area of the subject.