Bioadhesive Oral Strips for Microbiome Modulation
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Solution Overview
Problem
Current treatments for sore throat, headaches, migraines, depression, and other conditions associated with the oral microbiome often rely on antibiotics, which can lead to antibiotic resistance, toxicity, and allergies, highlighting a need for preventative treatments that do not involve antibiotics.
Innovation Solution
The use of oral strips or bioadhesive patches that adhere to the mucosal membrane in the oral cavity, incorporating beneficial bacteria such as Lachnospira, Veillonella, Faecalibacterium, and Rothia, along with CRISPR-modified bacteria, to promote the growth of beneficial bacteria and reduce pathogenic bacteria populations, thereby enhancing oral health and potentially treating various conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antibiotics are used to treat oral conditions, then pathogenic bacteria are reduced, but antibiotic resistance, toxicity, and allergies increase
Solution Approach 1:
The patent uses beneficial bacteria as intermediary organisms that compete with pathogenic bacteria for resources and space, indirectly reducing pathogen populations without direct antimicrobial action. This probiotic approach mediates the treatment effect through ecological competition rather than direct killing, avoiding antibiotic resistance and toxicity issues
Solution Approach 2:
The patent converts the concept of bacterial competition from a harmful interaction (pathogens outcompeting beneficial bacteria) into a beneficial treatment mechanism by introducing beneficial bacteria that outcompete pathogens. The same competitive principle that causes disease is harnessed therapeutically by introducing superior competitors (beneficial bacteria) to displace harmful ones
2Quantity of substance
If beneficial bacteria are introduced to oral cavity, then beneficial bacteria populations increase, but device complexity increases due to bioadhesive strip requirements
Solution Approach 1:
The patent employs thin bioadhesive strips that conform to oral mucosal surfaces, providing a simple yet effective delivery platform. These flexible thin films carry beneficial bacteria directly to the target site, minimizing device complexity while ensuring effective colonization and population increase of beneficial bacteria
Solution Approach 2:
The beneficial bacteria are designed to self-adhere and self-colonize on oral surfaces once delivered via the bioadhesive strip. The bacteria perform their own attachment and multiplication functions without requiring complex external control systems, reducing overall system complexity while achieving population increase
Data Source
AI summary
A method and system for increasing beneficial bacteria populations in a subject's oral cavity and decreasing pathogenic bacteria to address a variety of diseases and conditions, thereby enhancing a person's oral and overall health, including through the use of oral strips that adhere to surfaces in the oral cavity and that include at least one of xylitol, Lachnospira, Veillonella, Faecalibacterium and/or Rothia bacteria, including bacteria transformed via a CRISPR system. Certain embodiments employ light to modify oral cavity bacterial populations, including the use of bioluminescent oral strips that promote the growth of beneficial bacteria and decrease pathogenic bacteria populations.