Oral Anti-Ageing Supplement Targeting Cellular Mechanisms
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Solution Overview
Problem
Current anti-ageing solutions focus on temporary remedies for visible signs of ageing, failing to address the underlying cellular mechanisms that contribute to ageing, and there is a lack of an optimal blend of anti-ageing molecules that effectively counteract cellular ageing.
Innovation Solution
An oral anti-ageing composition comprising a mixture of NAD+ precursors, stilbenoids, pomegranate extract, sulforaphane, and Vitamin D, which targets multiple cellular ageing pathways, including mitochondrial function and epigenetic markers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Shape
If cosmetic treatments targeting visible signs of ageing are used, then skin appearance is improved, but underlying cellular ageing mechanisms are not addressed
Solution Approach 1:
The patent extracts and addresses the root cause of ageing by targeting cellular mechanisms (NAD+ depletion, sirtuin activity, mitochondrial function) rather than just treating visible symptoms. The composition penetrates to act on fundamental cellular processes, separating the treatment of underlying causes from surface-level effects.
Solution Approach 2:
The supplement acts preventively by maintaining NAD+ levels and sirtuin activity before significant cellular ageing occurs. By providing NAD+ precursors and supporting mitochondrial function early, the composition prevents the accumulation of cellular damage rather than reversing established ageing.
2Reliability
If pharmaceutical treatments for ageing symptoms are administered, then specific ageing symptoms are treated, but preventive effects on cellular ageing are limited
Solution Approach 1:
The composition enables preventive intervention by providing NAD+ precursors (NR, NMN, niacin) that maintain cellular health before ageing symptoms manifest. This shifts the timing of effective intervention from reactive (after ageing sets in) to proactive (before cellular decline accelerates).
Solution Approach 2:
The multi-component formulation addresses multiple ageing pathways simultaneously (NAD+ metabolism, sirtuin activation, mitochondrial function, oxidative stress), providing broad preventive coverage against various ageing-related conditions rather than targeting single symptoms.
3Device complexity
If a single anti-ageing component is used, then the formulation is simple, but the ability to counteract multiple ageing mechanisms is insufficient
Solution Approach 1:
The patent combines multiple anti-ageing components (NAD+ precursors, resveratrol, pomegranate extract, sulforaphane, vitamin D) into a synergistic formulation. Each component targets different ageing mechanisms, and their combination provides comprehensive coverage of cellular ageing pathways while maintaining manageable formulation complexity.
Solution Approach 2:
The composition merges components that act on different aspects of cellular ageing (NAD+ metabolism, antioxidant defense, mitochondrial function, epigenetic regulation) into a single integrated supplement, allowing simultaneous multi-target intervention without requiring multiple separate products.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively delays or prevents cellular ageing by maintaining high levels of NAD+, activating sirtuins, and reducing oxidative stress, thereby improving overall cellular health and biological age.
Implementation Method 1
The family of sirtuin proteins is assigned an important role in anti-ageing processes of cells, including through their role in (de) acetylation of DNA and proteins and their link to the intracellular pool of NAD+, an essential co-factor for cell health.
Implementation Method 2
The family of sirtuin proteins is assigned an important role in anti-ageing processes of cells, including through their role in (de) acetylation of DNA and proteins
Implementation Method 3
The mitochondria are the cell's energy factories, and impairment of the mitochondria, for example by oxidative stress, is also linked to cell ageing.
Implementation Method 4
Sulforaphane or a source of sulforaphane
Implementation Method 5
Vitamin D
Data Source
AI summary
The present invention relates to an oral anti-ageing composition comprising a mixture of:—At least one ingredient chosen from the group of niacinamide mononucleotide (NMN), niacinamide riboside (NR) and niacin-Resveratrol and/or pterostilbene —Pomegranate extract and/or-Sulforaphane or a source of sulforaphane; and—Vitamin D.