Organ Chip Porous Membrane Structure for Stretching Durability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Traditional cell culture models and animal experiments fail to accurately simulate the complex physiological functions of biological tissues and organs, and existing organ chips with porous hydrogel membranes are prone to damage during stretching and contraction due to insufficient strength.
Innovation Solution
A bionic organ device comprising an organ chip with a porous membrane made of a polymer material fiber mesh coated with a hydrophilic polymer material, enhancing breathability and strength to withstand repeated stretching and contraction without damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If porous hydrogel membranes are used in organ chips to simulate stretching and contraction, then the physiological environment is better reconstructed, but the membranes are prone to damage due to insufficient strength
Solution Approach 1:
The patent uses a composite structure consisting of a porous substrate layer and a hydrogel coating layer. The porous substrate provides mechanical strength and structural support, while the hydrogel layer maintains breathability and physiological functionality. This composite material approach resolves the contradiction between strength and breathability by combining materials with complementary properties.
Solution Approach 2:
Different layers of the membrane have different functional properties: the porous substrate layer is optimized for mechanical strength and structural integrity, while the hydrogel coating layer is optimized for breathability and cell interaction. This local differentiation of material properties allows each layer to excel at its specific function without compromising the other.
2Duration of action of moving object
If porous hydrogel membranes are subjected to significant stretching and contraction, then organ function simulation is improved, but the membranes are prone to damage
Solution Approach 1:
The composite structure with porous substrate and hydrogel coating allows the membrane to withstand repeated stretching and contraction cycles. The porous substrate provides the mechanical framework that maintains integrity during dynamic operations, while the hydrogel layer flexes with the tissue simulation requirements.
Solution Approach 2:
The porous substrate layer acts as a protective framework that prevents the hydrogel layer from suffering damage during stretching and contraction. This pre-established structural support cushions the softer hydrogel material against mechanical failure, extending the membrane's service life.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides precise control over the microenvironment, improves reliability, and extends the service life of the organ chip by ensuring the porous membrane can withstand multiple cycles of stretching and contraction without damage.
Implementation Method 1
The porous membrane is disposed between the first body and the second body and comprises a polymer material fiber mesh and a hydrophilic polymer material coating. The polymer material fiber mesh has a plurality of pores
Data Source
AI summary
A bionic organ device comprising an organ chip. The organ chip comprises a first body, a second body, and a porous membrane, where the porous membrane is disposed between the first and second bodies, and the porous membrane comprises a polymer fiber mesh and a hydrophilic polymer coating. The polymer fiber mesh has a plurality of pores, and the hydrophilic polymer coating coats the polymer fiber mesh.