Organ Perfusion System with Automated Fluid Composition Control
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Solution Overview
Problem
Current perfusion systems for organs lack automated control over fluid composition and pressure, leading to suboptimal conditions for organ preservation and transplantation, particularly in maintaining target ranges for oxygen, carbon dioxide, and nutrient levels during extracorporeal organ perfusion.
Innovation Solution
A perfusion system with a circuit for circulating fluid through an organ, incorporating adjustment and measurement means to control oxygen, carbon dioxide, and nutrient levels, along with pressure management, using sensors and control systems to maintain target ranges and detect bubbles, fluid leakage, and organ presence, enabling automated operation and portability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If automated control systems are implemented to maintain target ranges for oxygen, carbon dioxide, and nutrient levels, then organ preservation quality is improved, but device complexity increases
Solution Approach 1:
The system incorporates sensors that continuously monitor oxygen, carbon dioxide, and nutrient levels in the perfusion fluid, feeding this information back to a control system that automatically adjusts component concentrations to maintain target ranges, thereby ensuring optimal organ preservation quality through closed-loop control
Solution Approach 2:
The control system automatically regulates the composition of perfusion fluid by adjusting oxygen, carbon dioxide, and nutrient levels based on sensor feedback, enabling the system to self-correct and maintain optimal conditions without continuous manual intervention, thus improving reliability while managing complexity through automation
2Manufacturing precision
If precise measurement and control of fluid composition components are implemented, then perfusion effectiveness is improved, but manufacturing complexity increases
Solution Approach 1:
The system replaces manual monitoring and adjustment mechanisms with electronic sensors and automated control systems that precisely measure and regulate oxygen, carbon dioxide, and nutrient levels, achieving high manufacturing precision through electronic control rather than mechanical adjustment
Solution Approach 2:
The control system dynamically adjusts multiple parameters including oxygen concentration, carbon dioxide levels, and nutrient content to maintain optimal ranges, using electronic regulation to achieve precise control over fluid composition parameters without complex mechanical intervention
3Object-affected harmful factors
If automated detection and response systems for bubbles and fluid leakage are added, then safety is improved, but device complexity increases
Solution Approach 1:
The system incorporates sensors that detect bubbles and fluid leakage conditions before they can cause harmful effects to the organ, enabling early intervention and corrective action to prevent damage from these harmful factors
Solution Approach 2:
Sensors continuously monitor for the presence of bubbles and fluid leakage, providing feedback to the control system that automatically responds to these conditions, thereby preventing harmful effects through real-time detection and correction
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system ensures precise control of perfusion fluid composition and pressure, enhancing organ preservation by maintaining optimal conditions, detecting anomalies, and facilitating efficient and safe perfusion processes, including automated detection and response to bubbles and fluid secretions.
Implementation Method 1
Where the at least one component comprises oxygen, the adjustment means may comprise oxygen adding means arranged to add oxygen into the fluid. For example it may comprise an oxygenator.
Implementation Method 2
Where the at least one component comprises carbon dioxide, and the adjustment means may comprises carbon dioxide extraction means arranged to extract carbon dioxide from the fluid. This may be arranged to supply air, or another gas, which can absorb or extract carbon dioxide from the fluid.
Implementation Method 3
measuring means for measuring the content of said at least one component in the perfusion fluid
Implementation Method 4
The system may comprise a thermometer arranged to measure the temperature of the fluid. The system may comprise thermal adjustment means arranged to adjust the temperature of the fluid.
Data Source
AI summary
An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.