Organic Electrochemical Sensor for Multi-Analyte Heart Failure Monitoring
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Solution Overview
Problem
Current blood testing methods for heart failure rely on clinical chemistry in laboratories or point-of-care devices, which are not suitable for home monitoring and require multiple sensors for detecting multiple analytes, leading to high costs and complexity, and do not provide early indications for medication adjustments.
Innovation Solution
An organic electrochemical sensor with multiple functionalized channels and gates for simultaneous detection of four analytes in a single sample, including enzymatic, affinity, and ion recognition layers, allowing for compact, cost-effective, and sensitive monitoring of heart failure biomarkers without sample preparation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple individual OECTs with different functionalization are used to detect multiple analytes, then the detection capability for multiple analytes is improved, but the device complexity and manufacturing costs increase
Solution Approach 1:
The patent combines multiple OECTs with different functionalizations into a single integrated sensor device. Multiple channels (C1-C4) are merged into one device structure, allowing simultaneous detection of multiple analytes (BNP, NT-proBNP, creatinine, creatine) in a single sample without requiring separate devices for each analyte.
Solution Approach 2:
The sensor device achieves multi-functionality by incorporating channels with different recognition layers (affinity layers for BNP/NT-proBNP, enzymatic layers for creatinine/creatine) within a single device. This universal design allows one device to perform multiple detection functions that previously required separate specialized sensors.
2Adaptability or versatility
If multiple individual OECTs with different functionalization are used to detect multiple analytes, then the detection capability for multiple analytes is improved, but the manufacturing costs increase
Solution Approach 1:
By merging multiple detection channels into a single integrated sensor, the patent reduces the total number of components that need to be manufactured and assembled. This consolidation lowers manufacturing costs compared to producing and integrating multiple separate OECT devices.
Solution Approach 2:
The device is segmented into multiple functional channels (C1-C4) with specific recognition layers, allowing modular manufacturing of channel components that can be integrated into a single device. This segmentation enables cost-effective production while maintaining multi-analyte detection capability.
3Measurement precision
If clinical chemistry in laboratories or point-of-care devices is used for blood testing, then the measurement precision is improved, but the ease of operation and accessibility for home monitoring deteriorate
Solution Approach 1:
The sensor device enables patients to perform their own blood testing at home using a single drop of blood. The integrated design with multiple functional channels allows the device to automatically detect multiple analytes without requiring laboratory equipment or professional operation, making precision medical testing accessible to patients themselves.
Solution Approach 2:
The multi-functional sensor performs multiple analyte detections simultaneously in a single simple operation. Instead of requiring separate tests for different biomarkers, the universal sensor detects BNP, NT-proBNP, creatinine, and creatine together, maintaining comprehensive monitoring capability while simplifying the user process to a single blood drop application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables remote, easy-to-use monitoring of heart failure biomarkers, reducing hospital visits by providing early indications for medication adjustments and minimizing manufacturing costs through compact sensor design.
Implementation Method 1
organic electrochemical sensor for the detection of analytes in a physiological sample
Implementation Method 2
enzymatic recognition layer configured to detect a target analyte by an enzymatic reaction with the sample
Implementation Method 3
affinity recognition layer configured to detect a target analyte in the sample by a specific molecular binding with the sample
Data Source
Figure 1~2
Figure 3~4
Figure 5A
AI summary
The invention relates to an organic electrochemical sensor for the detection of analytes in a physiological sample, the sensor comprising at least three organic electrochemical transistors.