Organic Compound Nanopowder Production Using Carbohydrate Milling Medium

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Solution Overview

Problem

The wet milling method using salt particles as a milling medium is inefficient due to the need for large salt quantities that must be removed post-milling to avoid contamination, and it can lead to rust issues in the milling apparatus, increasing costs and complexity.

Innovation Solution

A method involving the use of a granular carbohydrate compound, such as sugar or sugar alcohol, in a ratio of at least 0.3 times the mass of the organic compound, for milling, which eliminates the need for salt removal and reduces rust risks, while achieving nano-powder particle sizes of 500 nm or less.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If salt particles are used as milling medium, then nano-powder can be produced, but large amount of salt must be removed post-milling causing contamination and increased process complexity

Engineering Contradiction:

Improveparticle size controlVSAvoidprocess complexity

Core Design Contradiction:

Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent extracts the harmful milling medium (salt particles) from the process by using carbohydrate compounds instead, which do not require removal and do not cause contamination, thereby simplifying the overall process while maintaining effective milling capability

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses carbohydrate compounds as a disposable milling medium that is consumed or easily removed during the process, eliminating the need for complex removal equipment and post-processing steps required for salt particle removal

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Productivity

If salt particles are used as milling medium, then milling can be performed, but rust issues occur in milling apparatus increasing costs

Engineering Contradiction:

Improvemilling efficiencyVSAvoidrust contamination

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful effect of salt particles causing rust into a beneficial situation by using carbohydrate compounds that are non-corrosive, thereby eliminating rust problems while maintaining milling efficiency

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent introduces carbohydrate compounds as an intermediary milling medium that performs the mechanical milling function without causing rust, acting as a substitute between the milling apparatus and the organic compound

Inventive Principle:

Principle #24Intermediary (Mediator)

3Quantity of substance

If wide particle diameter distribution is present, then coarse particles can be included, but suspension stability decreases

Engineering Contradiction:

Improveparticle size rangeVSAvoidsuspension stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent changes the particle size distribution parameters by controlling the milling process to achieve a narrow distribution with D50 of 0.5-5 μm and D90 of 10 μm or less, which optimizes suspension stability while maintaining adequate particle size for the application

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for the efficient production of organic compound nano-powders with reduced contamination and lower costs, maintaining particle size distribution stability post-milling without the need for water-washing or specialized rust-resistant equipment.

Implementation Method 1

Nano-powder with a narrow particle diameter distribution can be obtained by applying such a mechanical impact or a grinding force to the particles of the organic compound

Methodology Applied

Scientific EffectMechanical impact and grinding: Impact Force

Implementation Method 2

a method for milling the organic compound by a bead mill using beads made of ceramic, glass, or the like is well known

Methodology Applied

Scientific EffectAbrasion: Abrasion

Implementation Method 3

dispersing the mixture with an anti-agglomeration agent after wet-milling

Methodology Applied

Scientific EffectDispersion: Dispersion (of waves)

Implementation Method 4

liquid in which the organic compound is insoluble or poorly soluble

Methodology Applied

Scientific EffectSuspension: Suspension

Data Source

PatentEP2848243B1Organic compound nanopowder, production method therefor, and suspension

Publication Date: 2023.07.12 ACTIVAS PHARMA

AI summary

OBJECT The object of present invention is to provide an organic compound nano-powder conveniently, with low cost and with less contamination of impurities to be removed. MEANS FOR SOLVING The present inventions relate an organic compound nano-powder comprising a granular organic compound with an average particle diameter of 500 nm or less and a 90%-diameters of less than 1500 nm and a carbohydrate compound comprising at least any one of a sugar and a sugar alcohol and with amount of 0.3 times or more by mass relative to amount of the organic compound, a method for producing the same, and a suspension having the organic compound dispersed in a liquid dispersion medium in which the organic compound is insoluble or poorly soluble.