Body Orifice Delivery Valve for Predetermined Dose and Mucosal Absorption
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Solution Overview
Problem
Existing devices neglect either the need to deliver sufficient material to the target site or ensure adequate absorption into and through the mucosal layer, failing to provide an efficient system for substance delivery.
Innovation Solution
A device with a valve mechanism and pressurized gas system that allows for precise delivery of a predetermined amount of substance to a body orifice, featuring an active and inactive configuration, and a trigger mechanism to control delivery, enhancing absorption through the use of mucoadhesive agents and permeability enhancers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If improvements are made to the delivery device to enhance material delivery to the target area, then the quantity of substance delivered is improved, but the absorption of the compound into and through the mucosal layer is neglected
Solution Approach 1:
The patent applies composite materials by combining multiple substances in the formulation, including penetration enhancers and mucoadhesive agents with the active compound. This composite approach enables simultaneous achievement of sufficient material delivery and enhanced mucosal absorption, resolving the contradiction between quantity delivered and absorption reliability
2Reliability
If improvements are made to the composition or formulation to enhance absorption into and through the mucosal layer, then the absorption is improved, but the delivery of sufficient amount of material to the desired tissue is neglected
Solution Approach 1:
The patent merges multiple functional components into a single integrated formulation delivered by the device. The composition combines active compounds, penetration enhancers, and mucoadhesive agents, while the device integrates pressurized gas delivery with controlled valve mechanisms. This merging ensures both sufficient quantity delivery and enhanced absorption occur simultaneously
3Measurement precision
If a valve mechanism with multiple configurations and trigger mechanism is added to control predetermined delivery, then the precision of delivery is improved, but the device complexity increases
Solution Approach 1:
The patent employs pneumatic principles by using pressurized gas stored in a reservoir to drive the delivery mechanism. The gas pressure actuates the valve mechanism and trigger system, enabling precise predetermined delivery control through fluid pressure rather than complex mechanical linkages, thus managing device complexity while maintaining precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures efficient delivery and absorption of substances like peptides, proteins, and biologics to target tissues, improving user compliance and efficacy by providing a predetermined and controlled release mechanism.
Implementation Method 1
the pressurized gas, once the valve is reconfigured from the INACTIVE CONFIGURATION to the ACTIVE CONFIGURATION, is adapted to entrain the substance and deliver the same to the body orifice
Implementation Method 2
the substance comprises a mucoadhesive agent such as, but not limited to, bioadhesive proteins, carbohydrates and mucoadhesive polymers
Implementation Method 3
the substance comprises a penetration enhancer selected from a group consisting of a micro-emulsion, a nano-emulsion of the following: a surfactant, a part of a surfactant, an oil, a co-surfactant, an aqueous phase and any combination thereof; the penetration enhancer allowing: better absorption in the mucosal tissue, better permeation and absorption in the target cells
Data Source
AI summary
A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d) a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; and e) a fluid tight chamber.