Improved OSA-Starch Matrix for Stable Fat-Soluble Emulsions

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Solution Overview

Problem

Existing compositions using modified polysaccharides as matrices for fat-soluble active ingredients and colorants often exhibit variable physical parameters due to quality differences in the polysaccharides, necessitating standardized or improved polysaccharides for consistent performance.

Innovation Solution

The development of improved OSA-starches, which are produced through a process involving enzymatic and chemical hydrolysis, followed by separation techniques like centrifugation and microfiltration, to create a standardized matrix for compositions containing fat-soluble active ingredients and colorants, such as β-carotene, enhancing emulsifying properties and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If modified polysaccharides are used as matrix for compositions containing fat-soluble active ingredients and colorants, then the compositions can provide enrichment, fortification and coloration functions, but the physical parameters of the compositions vary due to quality differences in the modified polysaccharides

Engineering Contradiction:
Improveconsistency of physical parametersVSAvoidquality standardization of modified polysaccharide
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by precisely controlling the degree of substitution (DS) of the OSA-starch within specific ranges (0.05-0.50, preferably 0.10-0.30), molecular weight distribution, and moisture content (5-20%). These parameter specifications ensure consistent physical properties of the matrix that directly affect composition quality, resolving the reliability issue caused by variable polysaccharide quality

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent implements preliminary action by pre-processing the OSA-starch through controlled hydrolysis and purification steps before use in compositions. The starch is pre-modified with octenyl succinic anhydride under controlled conditions to achieve target DS values, and pre-screened for quality parameters, ensuring consistent performance in final compositions without variability from raw material differences

Inventive Principle:
Principle #10Preliminary action

2Reliability

If OSA-starch with high degree of substitution is used to improve emulsifying properties, then the emulsifying capacity increases, but the solubility and physical stability may deteriorate

Engineering Contradiction:
Improveemulsifying capacityVSAvoidphysical stability of composition
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent optimizes the degree of substitution parameter within a specific range (0.05-0.50, preferably 0.10-0.30) to balance emulsifying capacity with physical stability. This parameter optimization ensures that the OSA-starch provides sufficient hydrophobic interaction for emulsification while maintaining adequate solubility and compositional stability, resolving the contradiction between enhanced emulsifying properties and potential stability deterioration

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The improved OSA-starches result in more stable and efficient emulsions with improved solubility and film-forming properties, ensuring consistent enrichment, fortification, and coloration of food, beverages, animal feed, cosmetics, and pharmaceutical compositions.

Implementation Method 1

The improved OSA-starches result in more stable and efficient emulsions with improved solubility and film-forming properties

Methodology Applied
Scientific EffectEmulsification: Emulsion

Implementation Method 2

produced through a process involving enzymatic and chemical hydrolysis, followed by separation techniques like centrifugation and microfiltration

Methodology Applied
Scientific EffectCentrifugation: Centrifugal Separation

Implementation Method 3

produced through a process involving enzymatic and chemical hydrolysis, followed by separation techniques like centrifugation and microfiltration

Methodology Applied
Scientific EffectMicrofiltration: Filter (physical)

Implementation Method 4

produced through a process involving enzymatic and chemical hydrolysis

Methodology Applied
Scientific EffectEnzymatic hydrolysis: Hydrolysis

Implementation Method 5

produced through a process involving enzymatic and chemical hydrolysis

Methodology Applied
Scientific EffectChemical hydrolysis: Hydrolysis

Implementation Method 6

The improved OSA-starches result in more stable and efficient emulsions with improved solubility and film-forming properties

Methodology Applied
Scientific EffectFilm-forming: Deposition (physical)

Data Source

PatentEP1981915B1Compositions of active ingredients
Publication Date: 2018.04.25 DSM IP ASSETS BV
  • EP1981915B1 patent drawingFigure 1
  • EP1981915B1 patent drawingFigure 2
  • EP1981915B1 patent drawingFigure 3

AI summary

The present invention relates to compositions containing fat-soluble active ingredients and/or colorants in a matrix based on improved modified polysaccharides, i.e. modified polysaccharides where parts were separated, and to a process for preparing these compositions as well as to these improved modified polysaccharides themselves and a process for the manufacture thereof. The present invention further relates to the use of the compositions of this invention for the enrichment, fortification and/or for the coloration of food, beverages, animal feed, cosmetics and pharmaceutical compositions and to such food, beverages, animal feed, cosmetics and pharmaceutical compositions themselves.