Osteomedullary Tissue Processing System for Spinal Fusion
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Solution Overview
Problem
Current bone grafting methods face challenges such as the need for additional surgical procedures, pain, and complications like bone cement leakage and foreign body reactions, particularly in spinal fusion and trauma surgeries, where autografts are not always feasible and synthetic materials may not provide optimal bioactivity.
Innovation Solution
A bone graft preparation and delivery system that harvests and processes autologous osteomedullary tissue using a device with a needle and collection vessel, allowing for efficient aspiration and separation of bone fragments and cells, which are then mixed with an osteoconductive matrix to form a bone graft, minimizing surgical burdens and enhancing bioactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autograft is used for bone grafting, then osteoconductive, osteoinductive and osteogenic properties are improved, but additional surgical procedures and post-operative pain increase
Solution Approach 1:
The invention combines bone marrow aspiration, tissue processing, and bone graft delivery into a single integrated system. The needle aspirates bone marrow, the collection vessel processes and concentrates the osteogenic cells, and the system delivers the prepared graft material without requiring separate surgical procedures for graft harvest and delivery.
Solution Approach 2:
The system uses the patient's own bone marrow to generate the bone graft material in-situ. The osteogenic cells are harvested from the patient's bone marrow, concentrated and processed through the device, then delivered back to the surgical site, eliminating the need for separate autograft harvesting procedures.
2Device complexity
If synthetic bone graft materials are used, then device complexity is reduced, but osteogenic properties and bioactivity deteriorate
Solution Approach 1:
The system creates a composite bone graft by combining concentrated osteogenic cells from bone marrow with osteoconductive matrix materials. This composite approach provides both the biological activity of living cells and the structural support of synthetic or natural matrices, achieving enhanced osteogenic properties while maintaining material simplicity.
3Reliability
If bone marrow aspiration is performed to harvest osteogenic cells, then osteogenic properties are improved, but procedural complexity and time increase
Solution Approach 1:
The system performs preliminary concentration and processing of bone marrow cells during the aspiration procedure itself. The collection vessel is designed to concentrate osteogenic cells as they are aspirated, preparing the graft material in advance before delivery, thereby reducing subsequent processing time.
Solution Approach 2:
The system maintains continuous operation from bone marrow aspiration through cell concentration to graft delivery without interruption. The integrated design allows bone marrow to be aspirated, processed, and delivered as a continuous process, eliminating idle time between separate procedural steps.
4Quantity of substance
If large quantity of bone graft material is required for joint revision, then graft effectiveness is improved, but tissue harvesting burden increases
Solution Approach 1:
The system changes the concentration parameter of osteogenic cells by aspirating large volumes of bone marrow and concentrating the cellular content. This parameter change allows generation of sufficient graft volume with high cellular density, providing the required quantity without proportionally increasing harvesting burden.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system enables safe, efficient, and high-yield harvesting of bone fragments and stem cells, reducing the need for additional surgeries and improving bioactivity, resulting in a more effective bone graft with enhanced osteogenic properties for spinal fusion and trauma surgeries.
Implementation Method 1
harvests and processes autologous osteomedullary tissue using a device with a needle and collection vessel, allowing for efficient aspiration and separation of bone fragments and cells
Data Source
AI summary
A bone graft preparation and delivery system including a main body shaft, a bone graft matrix, a first end cap, a second end cap and a plunger. The main body shaft has a first end and a second end. The main body shaft has a main body shaft bore that extends between the first end and the second end. The bone graft matrix is placed in the main bore shaft. The first end cap is attachable to the first end. The second end cap is attachable to the second end. The bone graft preparation and delivery system is operable in a bone graft preparation configuration and a bone graft delivery configuration. When the bone graft preparation and delivery system is in the bone graft preparation configuration, the first end cap and the second end cap are attached to the main body shaft. When the bone graft preparation and delivery system is in the bone graft delivery configuration, the plunger is extendable through the main body shaft bore.