Ostomy Barrier Probiotic Adhesion Microbial Dysbiosis
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Solution Overview
Problem
Current ostomy barriers and adhesives fail to effectively manage peristomal skin dysbiosis and infections due to microbial growth, exacerbated by immunosuppression in ostomy patients, leading to impaired healing and complications.
Innovation Solution
Incorporating non-pathogenic bacteria, fungi, algae, or yeast into ostomy barriers and adhesives to promote healthy skin flora by selectively suppressing pathogenic organisms through controlled environmental conditions and nutritional media.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional adhesives and ostomy barriers are used to secure the appliance to skin, then adhesion and sealing are achieved, but pathogenic microbial growth is promoted leading to peristomal skin dysbiosis and infections
Solution Approach 1:
The patent converts the harmful warm, dark, and moist peristomal environment that promotes pathogenic growth into a beneficial setting for non-pathogenic probiotic bacteria. By introducing probiotic organisms into the adhesive composition, the same environmental conditions that were previously harmful now support beneficial microbial populations that compete with and suppress pathogenic organisms, thereby maintaining adhesion reliability while preventing infections.
Solution Approach 2:
The patent introduces probiotic bacteria as an intermediary between the adhesive material and the peristomal skin. These probiotic organisms act as mediators that modify the microenvironment by consuming available nutrients and producing metabolic byproducts that create an unfavorable conditions for pathogenic bacteria, thus preventing dysbiosis without compromising the adhesive's sealing function.
2Stability of the object's composition
If the peristomal environment is kept warm, dark, and moist to maintain skin health, then skin viability is preserved, but microbial proliferation is enhanced leading to infections
Solution Approach 1:
The patent applies local quality by creating a differentiated microbial ecosystem within the peristomal environment. The adhesive composition is formulated to selectively support the growth of specific non-pathogenic probiotic bacteria while抑制ing pathogenic organisms. This localized modification of microbial composition allows the warm, dark, and moist conditions to maintain skin viability without enabling harmful microbial proliferation.
Solution Approach 2:
The patent changes the biological parameters of the peristomal environment by introducing probiotic bacteria that alter the microbial balance. These probiotic organisms modify local conditions through their metabolic activities, producing substances that change the chemical and biological parameters of the environment to be unfavorable for pathogenic bacteria while maintaining conditions suitable for skin health.
3Reliability
If immunosuppressive therapies are administered to treat underlying conditions, then comorbidities are managed, but peristomal infection risk is increased
Solution Approach 1:
The patent applies preliminary action by pre-colonizing the peristomal skin with probiotic bacteria before pathogenic infections can establish themselves. The adhesive composition delivers beneficial microorganisms that occupy ecological niches and consume available nutrients in advance, creating a protective barrier that prevents opportunistic pathogens from infecting immunosuppressed patients undergoing necessary therapies.
4Productivity
If extended wear time is used to reduce appliance changes, then productivity is improved, but peristomal skin exposure to harmful microbes increases
Solution Approach 1:
The patent ensures continuity of useful action by incorporating probiotic bacteria into the adhesive that continuously suppress pathogenic organisms throughout the extended wear period. The probiotic organisms remain active and competitive throughout the appliance's wear duration, maintaining a protective microbial barrier that prevents infections even during prolonged exposure to the warm, moist peristomal environment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Maintains and improves peristomal skin health by promoting beneficial microbial populations, reducing pathogenic growth, and creating optimal microclimatic conditions for healing.
Implementation Method 1
The non-pathogenic microorganisms are hypothesized to alter the environment and/or offer competition to the pathogenic microorganisms and reduce their relative proportion of the total population.
Implementation Method 2
differential culture medium, nutrients and/or conditions have been historically and widely used in the identification and/or isolation of microorganisms and are well characterized in the literature. These same media, nutrients, and/or conditions can be used to selectively promote or suppress specific bacterial, fungal and/or viral species over others.
Implementation Method 3
A peristomal skin environment under an ostomy barrier is warm, dark, and moist
Implementation Method 4
differential culture medium, nutrients and/or conditions have been historically and widely used in the identification and/or isolation of microorganisms
Data Source
AI summary
An ostomy barrier, skin adhesive, accessory or a peristomal skin treatment comprises a population of non-pathogenic bacteria, fungi, algae, yeast or their lysates configured to limit proliferation of pathogenic organisms in or on peristomal skin or skin at other body sites and/or maintain healthy skin flora. The ostomy barrier, adhesive, accessory or peristomal skin treatment can also be configured to alter the peristomal or other skin environment to promote growth of a desirable or commensal population while discouraging growth of the pathogenic organisms.