Cooling Mixture of Oxamate and Polyols for Skin Sensation
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Solution Overview
Problem
Existing cooling substances for topical applications often require high concentrations to induce a noticeable cooling effect, which can lead to undesired side effects like stinging and burning, and many have a mint-like odor, limiting their suitability.
Innovation Solution
A cooling mixture comprising 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate combined with one or more polyols such as n-1,2-pentanediol, which enhances the cooling effect at lower concentrations, reducing the risk of side effects and odor issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If high concentrations of cooling substances are used to induce a tangible cooling effect, then the cooling intensity is improved, but undesired side effects such as stinging and burning occur
Solution Approach 1:
The patent changes the chemical parameters by introducing a novel cooling substance (5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate) with different molecular structure and properties from traditional cooling agents. This structural parameter change enables achieving cooling effect at lower concentrations (0.01-5% w/w), thereby resolving the contradiction between cooling intensity and harmful side effects
Solution Approach 2:
The patent creates a composite cooling formulation by combining the novel cooling substance with specific carriers and optional co-substances. This composite approach enhances the cooling efficiency and allows effective cooling at reduced concentrations, thus preventing stinging and burning while maintaining tangible cooling effect
2Temperature
If high concentrations of cooling substances are used to achieve a noticeable cooling effect, then the cooling effect is improved, but the complexity of managing side effects increases
Solution Approach 1:
By changing the concentration parameter to lower ranges (0.01-5% w/w), the patent simplifies formulation management and reduces the complexity of controlling side effects while maintaining effective cooling. The novel substance inherently provides cooling at these lower concentrations without requiring complex concentration adjustment protocols
3Temperature
If traditional cooling substances with mint-like odor are used, then the cooling effect is achieved, but the suitability for topical application is reduced
Solution Approach 1:
The patent changes the chemical structure parameters of the cooling substance to create 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate, which has different sensory properties including reduced or altered odor profile compared to traditional mint-based cooling agents. This structural modification maintains cooling efficacy while improving suitability for topical applications where odor may be problematic
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate with polyols provides a perceivable cooling effect at lower concentrations, enhancing the cooling intensity while minimizing side effects and odor, as demonstrated by a panel test where 90% of test subjects confirm a cooling sensation.
Implementation Method 1
Menthol binds to the TRPM8 (Transient Receptor Potential Melastatin 8) receptor also known under the designation of CMR (Cold Menthol Receptor 1). This receptor belongs to the family of TRPs (Transient Receptor Potential Ion Channels) and is expressed in specific peripheral neurons, where it forms a pore consisting of four protein monomers. Low temperatures as well as the binding of cooling substances to the channel will open the latter and will thus allow calcium and sodium ions to enter through the membrane.
Data Source
AI summary
The invention relates to a cooling mixture comprising or consisting of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate and one, two, three or more certain polyols. It further relates to a cosmetic composition comprising such a cooling mixture or to a sanitary article comprising such a cooling mixture. The invention also relates to the use of certain polyols for enhancing the cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate on the skin or a mucous membrane, a method for generating an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate on the skin or a mucous membrane as well as a method for generating a corresponding cooling mixture.