Oxamide Nanogel for Controlled CO2 Generation in Ultrasound Imaging
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Solution Overview
Problem
Current ultrasound imaging contrast agents for inflammatory diseases, particularly those generating CO2 from hydrogen peroxide, face challenges in efficiently capturing and utilizing the generated CO2 due to rapid reaction rates with oxalate bonds, leading to low signal enhancement and diagnostic accuracy.
Innovation Solution
A nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, combined with perfluorohexane, is developed to control CO2 generation rate and capture CO2 effectively, forming microbubbles for enhanced ultrasound imaging, particularly for inflammatory diseases like cancer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If oxalate bonds are used to generate CO2 from hydrogen peroxide, then CO2 generation occurs rapidly, but the reaction rate is too fast to capture CO2 effectively, leading to low signal enhancement
Solution Approach 1:
The patent changes the chemical bond type from oxalate to oxamide, which alters the reaction kinetics with hydrogen peroxide. Oxamide bonds generate CO2 at a controlled, slower rate that allows perfluorohexane to capture the CO2 effectively, resolving the contradiction between generation speed and capture efficiency
Solution Approach 2:
Perfluorohexane acts as an intermediary substance that mediates between CO2 generation and ultrasound signal enhancement. It captures CO2 as it is generated from oxamide bond cleavage, enabling effective signal enhancement while maintaining controllable reaction kinetics
2Quantity of substance
If perfluorohexane is used to capture CO2, then CO2 density increases and signal enhancement improves, but the system becomes more complex
Solution Approach 1:
The patent merges multiple functions into a single nanogel system: the polyamine-based polymer provides structural framework and hydrogen peroxide sensitivity, oxamide bonds provide controlled CO2 generation, and perfluorohexane provides CO2 capture and ultrasound contrast. This integration achieves high CO2 density and signal enhancement while managing system complexity through functional consolidation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanogel provides controlled CO2 generation and capture, significantly improving ultrasound signal enhancement and diagnostic accuracy for inflammatory diseases, including cancer, by forming microbubbles that support higher CO2 density and clearer lesion visualization.
Implementation Method 1
a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds... generating CO2 at inflammatory lesions
Implementation Method 2
capable of capturing the generated CO2, which is advantageous for signal enhancement of ultrasound imaging
Data Source
AI summary
The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.