Oxidative Agent Modulation of Macrophage Activation
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Solution Overview
Problem
Activated macrophages contribute to tissue damage and inflammation in various diseases, including cancer and autoimmune disorders, necessitating a method to modulate their activation or accumulation effectively.
Innovation Solution
Administration of a pharmaceutical composition containing an oxidative agent, such as chlorite, or an immunomodulatory agent to treat macrophage-related diseases by adjusting pH and incorporating pharmaceutically acceptable excipients, thereby modulating macrophage activation or accumulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If activated macrophages are used to fight pathogens and cellular debris, then immune defense capability is improved, but tissue damage and inflammation increase
Solution Approach 1:
The patent uses oxidative agents to change the activation state parameter of macrophages, transitioning them from an activated state (which causes tissue damage) to an inactivated state (which reduces inflammation), thereby resolving the contradiction between immune defense and tissue protection
Solution Approach 2:
The patent converts the harmful inflammatory response generated by activated macrophages into a beneficial therapeutic effect by using oxidative agents to modulate macrophage activation, transforming the harmful inflammation into controlled immune regulation that treats diseases while preserving immune function
2Object-generated harmful factors
If immunosuppressant agents are used to mitigate macrophage activation, then tissue damage is reduced, but immune defense capability is compromised
Solution Approach 1:
The patent employs oxidative agents (strong oxidants) to directly modulate macrophage activation states, providing a more selective and controllable approach compared to broad immunosuppressants, thereby reducing tissue damage while preserving necessary immune defense capabilities
Solution Approach 2:
The oxidative agents act as intermediaries that selectively modulate macrophage activation without broadly suppressing the entire immune system, allowing precise control over the harmful inflammatory response while maintaining overall immune defense capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively treats macrophage-related diseases by reducing inflammation and modulating macrophage activity, creating a non-inflamed environment that enhances the efficacy of other therapeutic agents.
Implementation Method 1
Oxidative agents such as chlorite can return macrophages to their inactivated state
Data Source
AI summary
The present invention provides a method of treating a macrophage related disease comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The present invention also provides a method of modulating macrophage accumulation or activation comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The oxidative agent can be chlorite or a chlorite containing compound.