Oxidative Bone Coatings for Accelerated Osseointegration
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Solution Overview
Problem
Current bone implant fixation techniques are inefficient, leading to prolonged healing times and insufficient bone integration, particularly in cases of natural bone insufficiency or inadequate jawbone density, necessitating a need to enhance osteoblast proliferation and accelerate bone growth for successful implantation and osseointegration.
Innovation Solution
A composition comprising a mixture of peracid and bis(hydroperoxide) is used to stimulate osteoblast growth, applied locally to bone wounds or defects, or coated on implants to promote bone calcification and fixation, potentially combined with magnesium salts to enhance osteogenic activity and reduce healing times.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional titanium implants are used without additional bone growth stimulation, then the implant can be placed immediately, but the osseointegration process is slow and may fail in patients with insufficient bone density
Solution Approach 1:
The patent applies oxidative compositions (peracids and bis-hydroperoxides) to the implant surface or surrounding bone tissue before osseointegration occurs. This preliminary chemical treatment stimulates osteoblast proliferation and bone formation in advance, creating a more favorable environment for subsequent implant integration and reducing the overall healing time.
Solution Approach 2:
The patent changes the chemical parameters of the bone tissue by introducing oxidative agents that modify the local environment. These chemical changes stimulate metabolic activity in osteoblasts and enhance bone formation rates, thereby accelerating the osseointegration process without compromising implant reliability.
2Quantity of substance
If bone grafting procedures are performed to rebuild insufficient bone, then bone mass can be increased, but the integration process takes three months or more
Solution Approach 1:
The patent employs strong oxidative agents (peracids and bis-hydroperoxides) applied to the bone graft or implant site. These oxidants accelerate the metabolic activity of osteoblasts and stimulate rapid bone formation, reducing the integration time from three months or more to a significantly shorter period while maintaining adequate bone mass accumulation.
3Volume of stationary object
If sinus lift or ridge expansion procedures are performed to augment bone, then sufficient bone volume can be achieved, but the healing period requires four to twelve months
Solution Approach 1:
The oxidative composition is applied during or immediately after sinus lift or ridge expansion procedures. This preliminary chemical stimulation of osteoblasts initiates accelerated bone formation processes, allowing the augmented bone volume to mature and integrate more rapidly than conventional healing timelines of four to twelve months.
Solution Approach 2:
The patent modifies the biochemical parameters of the augmented bone site by introducing oxidative agents. These chemical changes enhance cellular metabolism and bone formation rates, thereby reducing the healing period required for the augmented bone volume to become sufficiently mature for implant placement.
4Adaptability or versatility
If titanium implants are used in elderly patients with inadequate jawbone density, then implant placement can be attempted, but the implants frequently fail to fuse with the bone
Solution Approach 1:
The patent applies oxidative compositions locally to the implant site in elderly patients with inadequate bone density. This localized chemical treatment creates a favorable microenvironment for osteoblast activity specifically at the implant-bone interface, compensating for the patient's overall reduced bone formation capacity and improving osseointegration success rates.
Solution Approach 2:
The patent changes the local biochemical parameters at the implant site by introducing oxidative agents. These chemical modifications stimulate metabolic activity and bone formation capacity locally, enabling successful osseointegration in elderly patients who would otherwise be poor candidates due to their reduced bone healing capacity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly increases bone mass and calcification rates, accelerating the integration of implants and reducing the time required for bone graft integration, thereby improving implant fixation and osseointegration.
Implementation Method 1
Compositions and methods that play an important role in osteoblasts healing and regeneration of bone cells are disclosed. In one aspect of the present invention, there is provided a composition comprising a mixture of a peracid and a bis(hydroperoxide) for use in stimulating the growth of osteoblast cells.
Data Source
AI summary
Clinical application of oxidative compositions, alone or in combination with polymer or salt stabilizers, for use in bone proliferation applications, such as spinal surgery, arthroplasty, or osteosarcoma. Additional applications include use in dental artificial tooth implants, orthopedic implantable prostheses for small and large bones, implantation into other surgical sites (e.g., dental implants, bone graft additive, face reconstruction, etc.) where bone growth is desired.