Oxygen Concentrator for Organ Perfusion Gas Control
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Solution Overview
Problem
Current perfusion systems for organs lack efficient and controlled oxygenation and carbon dioxide management, which are crucial for maintaining optimal perfusion fluid conditions during extracorporeal organ preservation and transplantation.
Innovation Solution
A perfusion system that incorporates an oxygen concentrator, oxygenation means, and control mechanisms to regulate oxygen and carbon dioxide levels in the perfusion fluid, using sensors and valves to maintain target ranges, along with an air supply for carbon dioxide adjustment and a user interface for inputting limits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If an oxygen concentrator with nitrogen extraction means is used to supply oxygen, then the oxygen content in perfusion fluid can be precisely controlled, but the device complexity increases
Solution Approach 1:
The oxygen supply system is segmented into distinct functional modules: an oxygen concentrator for oxygen enrichment, a nitrogen extraction means for removing excess nitrogen, and a control system with oxygen sensors and flow control valves. This modular segmentation allows precise oxygen content control while managing device complexity through organized functional separation.
Solution Approach 2:
The system incorporates oxygen measuring means (oxygen sensors) that continuously monitor the oxygen content in the perfusion fluid and provide feedback to the control system. The control system adjusts the oxygen supply via flow control valves based on this feedback, enabling precise closed-loop control of oxygen content despite the added device complexity.
2Adaptability or versatility
If separate oxygen and air supplies are used for oxygenation and carbon dioxide management, then gas content control is improved, but the device complexity increases
Solution Approach 1:
The gas supply system is segmented into separate oxygen supply and air supply channels, each with its own flow control valve and measuring means. This segmentation enables independent control of oxygenation and carbon dioxide management, providing versatile gas content control while organizing complexity through functional separation.
Solution Approach 2:
The oxygenator is designed as a multi-functional device that simultaneously performs oxygenation (adding oxygen via oxygen supply) and carbon dioxide management (adding or removing CO2 via air supply). This universal device handles multiple gas control functions, improving adaptability while consolidating rather than increasing overall system complexity.
3Reliability
If automated control means with oxygen and carbon dioxide measuring means are implemented, then the reliability of perfusion fluid management is improved, but the device complexity increases
Solution Approach 1:
The control system incorporates oxygen measuring means and carbon dioxide measuring means that continuously monitor gas contents in the perfusion fluid and provide feedback signals. The control means automatically adjusts oxygen and air supply flow rates based on this feedback, ensuring reliable maintenance of target gas content ranges despite the increased control system complexity.
Solution Approach 2:
The automated control system with measuring means enables the perfusion system to self-regulate gas content parameters. The system automatically detects deviations from target ranges and adjusts supplies without manual intervention, improving reliability through self-monitoring and self-correction capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system ensures precise control of oxygen and carbon dioxide levels in perfusion fluids, enhancing the preservation and transplantation of organs by maintaining optimal gas content within defined ranges, thereby improving organ viability and safety.
Implementation Method 1
The oxygen concentrator may comprise nitrogen extraction means for extracting nitrogen from the air
Implementation Method 2
oxygenation means arranged to add oxygen into the fluid as the fluid circulates in the circuit
Implementation Method 3
an air supply arranged to supply air to the oxygenation means whereby the oxygenation means can add carbon dioxide to the perfusion fluid
Data Source
AI summary
A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit (16) for circulating perfusion fluid through the organ, oxygenation means (14) for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.