Oxygen Partial-Pressure Biosensor With Ether-Polymer Membrane
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Solution Overview
Problem
Conventional biosensors for measuring oxygen partial pressure in blood exhibit low accuracy due to the use of materials for the oxygen permeable membrane and insulating layer, resulting in a small electrode slope.
Innovation Solution
Incorporating an ether-containing organic polymer into the oxygen permeable membrane or insulating layer of the biosensor to enhance the electrode slope and improve accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional materials (silicone, polytetrafluoroethylene, cellulose acetate, polyvinyl chloride) are used for the oxygen permeable membrane and insulating layer, then the biosensor can be manufactured with existing materials, but the electrode slope is small and biosensor accuracy is insufficient
Solution Approach 1:
The patent changes the chemical composition parameter of the oxygen permeable membrane and insulating layer materials by incorporating ether-containing organic polymers (such as polyether sulfone, epoxy resin, or thermoplastic silicone polyether polyurethane) into the conventional materials. This parameter change increases the electrode slope from conventional values to at least 0.5 mV/mmHg, thereby improving biosensor accuracy while maintaining manufacturability through established coating and processing techniques
Solution Approach 2:
The patent creates composite materials by combining ether-containing organic polymers with conventional membrane materials (silicone, polytetrafluoroethylene, cellulose acetate, or polyvinyl chloride). The composite structure allows the biosensor to benefit from both the oxygen permeability of conventional materials and the slope-enhancing properties of ether-containing polymers, achieving high accuracy without completely abandoning existing material systems
2Ease of manufacture
If the oxygen permeable membrane and insulating layer are made with conventional materials, then the manufacturing process is simple and materials are readily available, but the electrode slope is limited and measurement accuracy is low
Solution Approach 1:
The patent modifies the chemical composition of the membrane and insulating layer by incorporating ether-containing organic polymers at specific concentrations (0.1-10% by weight). This parameter change enhances the electrode slope to at least 0.5 mV/mmHg while maintaining the simplicity of the manufacturing process, as the modified materials can be applied using conventional coating, extrusion, or lamination techniques already established in biosensor production
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of ether-containing organic polymers significantly increases the biosensor's slope, thereby improving its accuracy and efficiency in measuring oxygen partial pressure.
Implementation Method 1
When blood immerses the oxygen permeable membrane, oxygen in the blood permeates through the oxygen permeable membrane
Implementation Method 2
oxygen in the blood permeates through the oxygen permeable membrane and undergoes an electrochemical reaction on the working electrode, generating a current signal
Data Source
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AI summary
The present invention provides a biosensor for measuring the oxygen partial pressure, and a preparation method therefor. The biosensor comprises an electrode system and an insulating layer; the electrode system at least comprises a working electrode and a counter electrode; the working electrode is covered with an electrolyte layer; the electrolyte layer is covered with an oxygen permeable membrane; the oxygen permeable membrane or the insulating layer comprises an ether-containing organic polymer. According to the present invention, by using the oxygen permeable membrane or the insulating layer with an ether-containing organic polymer, the electrode slope can be remarkably increased, and the precision of a biosensor is improved.